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Human Synaptophysin Protein expressed in Wheat germ - ABIN1322008
Caviness, Lue, Beach, Hentz, Adler, Sue, Sadeghi, Driver-Dunckley, Evidente, Sabbagh, Shill, Walker: Parkinson's disease, cortical dysfunction, and alpha-synuclein. in Movement disorders : official journal of the Movement Disorder Society 2011
Show all 2 Pubmed References
In the amygdala, bold monkeys had higher levels of SYP mRNA than reserved monkeys
Synaptophysin decreases with age in the rhesus macaque brain similar to humans.
Syp can be quantified on circulating tumor cells and that Syp expression correlates with resistance to abiraterone and enzalutamide in castration resistant prostate cancer.
Report of a novel SYP mutation identified in a patient with a severe neurodevelopmental disorder. Mutation does not impact on synaptic vesicles endocytosis or trafficking of common cargoes. However it is unable to support sybII retrieval in synaptophysin knockout neurons. It fully restores plasma membrane levels of sybII, suggesting that activity-dependent trafficking of sybII is specifically affected by this mutation.
The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients.
Synaptophysin-positive epithelial proliferations suggest breast neoplasms.
Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56.
High synaptophysin expression is associated with neuroendocrine differentiation in colorectal cancer.
Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions.
Anomalous expression of all intermediate filament proteins and synaptophysin was found in significant subsets of malignant melanoma.
Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
This study demonstrated that synaptophysin was significantly lower in Down syndrome with Alzheimer disease compared with Down syndrome alone and similar to sporadic Alzheimer disease.
Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
The results of this study suggested that SYP may be primarily associated with ADHD-I and its genetic mechanism may be gender-specific.
The paucity or absence of synaptophysin-positive cells in all three phenotypes of Barrett's mucosa might mirror a sequela of chronic inflammation caused by the particular pathogenic bacteria present in the immediate oesophageal microenvironment.
Data suggest that multi-antibody assay of TTF1, Vimentin, p63 CD56, chromogranin and synaptophysin may be of special value, especially in diagnosing small biopsies.
the author showed that, in cutaneous basal cell carcinoma, the expression of NCAM and c-KIT was high, PDGFRA was intermediate, and chromogranin A and synaptophysin was relatively low
Depressed patients showed significant decreases in synaptophysin (SYN) and VGLUT1 expression.
Lower levels of synaptophysin were found in the visual cortex of dementia with Lewy bodies patients compared to controls.
Normal goblet cells found in duodenal adenomas express synaptophysin.
The data of this study suggested that the common polymorphisms of the SYP gene appear not to play a major role in conferring susceptibility to schizophrenia.
This is the first report of immunoreactivity for inhibin-alpha and synaptophysin in synovial sarcoma
The structure of SYP has been determined.
Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.
PSD95 and SYP may originate from the different sites, but they are closely related to the formation and maturation of synapse.
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN and PSD95 expression, which is critical for structural synaptic plasticity.
APP, tau, and synaptophysin were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 matters, suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior.
Syp1 clears Syb2 from the presynaptic active zone to prevent short-term depression.
HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab
The balance between synaptophysin and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin levels might affect the localisation of sybII and subsequent presynaptic performance.
The high expression of P2X7 receptor and low expression of synaptophysin in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure.
Trimethyltin decreased synaptophysin but not GAP-43 expression in the mouse hippocampus.
These studies suggest that the efficient retrieval of sybII by synaptophysin may be key to maintaining synaptic health and perturbation of this event may contribute to the pathogenesis underlying neurodevelopmental disorders.
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin levels.
Melatonin can reduce the expression levels of NF-kappaB p65 and synaptophysin in the brain tissue to protect the brain and slow down the aging process.
Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles.
Synaptophysin controls synaptobrevin (sybII)traffic in nerve terminals during synaptic vesicle (SV) endocytosis, an interaction that may act as an adjustable regulator of SV retrieval efficiency.
Cognitive improvement of schizophrenic histopathology may be related to a restoration of synaptophysin and/or Arc levels in the frontal cortex.
synaptophysin regulates at least two phases of endocytosis to ensure vesicle availability during and after sustained neuronal activity.
Data demonstrate that protein expression of synaptophysin decreases age-dependently in senescence-accelerated mouse/prone 8 mice and increases in a learning- and memory-dependent manner in KM mice.
The alteration of neuronal remodeling proteins in the hippocampus may be an underlying mechanism of venlafaxine in treating post-stroke depression.
Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons.
synaptophysin targeting to a ubiquitous synaptic vesicle-sized compartment is facilitated by cellugyrin and synaptogyrin
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).
, major synaptic vesicle protein P38
, major synaptic vesicle protein p38
, BM89 antigen
, Syp I