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Human Synaptophysin Protein expressed in Wheat germ - ABIN1322008
Caviness, Lue, Beach, Hentz, Adler, Sue, Sadeghi, Driver-Dunckley, Evidente, Sabbagh, Shill, Walker: Parkinson's disease, cortical dysfunction, and alpha-synuclein. in Movement disorders : official journal of the Movement Disorder Society 2011
Show all 2 Pubmed References
In the amygdala, bold monkeys had higher levels of SYP mRNA than reserved monkeys
Synaptophysin decreases with age in the rhesus macaque brain similar to humans.
Report of a novel SYP mutation identified in a patient with a severe neurodevelopmental disorder. Mutation does not impact on synaptic vesicles endocytosis or trafficking of common cargoes. However it is unable to support sybII (zeige VAMP2 Proteine) retrieval in synaptophysin knockout neurons. It fully restores plasma membrane levels of sybII (zeige VAMP2 Proteine), suggesting that activity-dependent trafficking of sybII (zeige VAMP2 Proteine) is specifically affected by this mutation.
The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients.
Synaptophysin-positive epithelial proliferations suggest breast neoplasms.
Suggest that INSM1 (zeige INSM1 Proteine) is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56 (zeige NCAM1 Proteine).
High synaptophysin expression is associated with neuroendocrine differentiation in colorectal cancer.
Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions.
Anomalous expression of all intermediate filament proteins and synaptophysin was found in significant subsets of malignant melanoma.
Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 (zeige DLG4 Proteine) decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
This study demonstrated that synaptophysin was significantly lower in Down syndrome with Alzheimer disease compared with Down syndrome alone and similar to sporadic Alzheimer disease.
Patterns of the immunoreactivity with antibodies to SNAP-25 (zeige SNAP25 Proteine), synapsin-I (zeige SYN1 Proteine) and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
The structure of SYP has been determined.
PSD95 (zeige DLG4 Proteine) and SYP (zeige PTPN11 Proteine) may originate from the different sites, but they are closely related to the formation and maturation of synapse.
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN and PSD95 (zeige DLG4 Proteine) expression, which is critical for structural synaptic plasticity.
APP (zeige APP Proteine), tau, and synaptophysin were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 matters, suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior.
Syp1 clears Syb2 (zeige VAMP2 Proteine) from the presynaptic active zone to prevent short-term depression.
HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab
The balance between synaptophysin and sybII (zeige VAMP2 Proteine) levels is critical for the correct targeting of sybII (zeige VAMP2 Proteine) to synaptic vesicles and suggests that alterations in synaptophysin levels might affect the localisation of sybII (zeige VAMP2 Proteine) and subsequent presynaptic performance.
The high expression of P2X7 receptor (zeige P2RX7 Proteine) and low expression of synaptophysin in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure.
Trimethyltin decreased synaptophysin but not GAP-43 (zeige GAP43 Proteine) expression in the mouse hippocampus.
These studies suggest that the efficient retrieval of sybII (zeige VAMP2 Proteine) by synaptophysin may be key to maintaining synaptic health and perturbation of this event may contribute to the pathogenesis underlying neurodevelopmental disorders.
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin levels.
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).
, major synaptic vesicle protein P38
, major synaptic vesicle protein p38
, BM89 antigen
, Syp I