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findings show that AGS3 is not required for planar divisions of neural progenitors in the mouse neocortex. AGS3 is not recruited to the cell cortex and does not rescue LGN (zeige GPSM2 Proteine) loss of function.
We conclude that LPS (zeige TLR4 Proteine) priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3 (zeige GNAI3 Proteine), AGS3, or RGS19 (zeige RGS19 Proteine); or had been treated with pertussis toxin, were similar to controls
AGS3 has a role in the regulation of G-protein signaling in the immune system
these results indicate that GRK6 (zeige GRK6 Proteine) complexes with AGS3-Galphai2 (zeige GNAI2 Proteine) to regulate CXCR2 (zeige CXCR2 Proteine)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease.
These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration.
AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure.
The GPR (zeige ALDH18A1 Proteine) motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase (zeige RACGAP1 Proteine) activator as initially suggested.
The G-protein Regulatory motif of AGS3 is critical for regulating MUC1/Muc1 (zeige MUC1 Proteine) expression and cytokine production in the inflammatory microenvironment.
Data support the notion that the Galpha (zeige SUCLG1 Proteine), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (zeige TRPC4 Proteine) activation and unveil new roles for RGS (zeige PITX2 Proteine) and AGS3 in fine-tuning TRPC4 (zeige TRPC4 Proteine) activities.
Activator of G-protein Signaling 3 is an important regulator of esophageal squamous cell carcinoma proliferation
Results confirmed that Ric-8A (zeige RIC8A Proteine) can directly bind to AGS3S but failed to facilitate Galpha (zeige SUCLG1 Proteine)(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha (zeige SUCLG1 Proteine)(i/o)-GDP complex in a cellular environment.
High GPSM1 gene methylation is associated with gastric tumor aggressiveness.
Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP (zeige LEP Proteine), GPSM1 and SLC16A13 (zeige SLC16A13 Proteine).
Our data indicate that decreased expression of AGS3 is correlated with reduced levels of p-CREB (zeige CREB1 Proteine) in the apoptotic model. The negative role of AGS3 in cell apoptosis was further confirmed by knocking down AGS3.
These results provide mechanistic insights into how reversible modulation of Galpha(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy.
AGS3 receptor coupling to both Galphabetagamma and GPR (zeige ALDH18A1 Proteine)-Galpha (zeige SUCLG1 Proteine)(i) offer additional flexibility for systems to respond and adapt to challenges and orchestrate complex behaviors
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
G-protein-signaling modulator 1
, activator of G-protein signaling 3
, G-protein signaling modulator 1 (AGS3-like, C. elegans)
, G-protein signalling modulator 1 (AGS3-like, C. elegans)
, G-protein signaling modulator 1 (AGS3-like)
, G-protein signaling modulator 1 L homeolog