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High CAV2 expression is associated with lung cancer.
A-type lamin (zeige LMNA Proteine)-dependent Caveolin-2 homo-oligomerization in the inner nuclear membrane microdomain is a precondition for pY19-Caveolin-2-mediated insulin (zeige INS Proteine)-response epigenetic activation at the nuclear periphery.
CAV-1 (zeige CAV1 Proteine) and -2 have roles in progression of prostate neoplasms
Caveolin-2 expression is necessary for the control of E2-dependent cellular proliferation of MCF-7 cells.
variant in CAV2 is associated with increased age-of-onset of P. aeruginosa airway infection in cystic fibrosis (zeige S100A8 Proteine) cohort.
The minor allele G of rs17588172 in the CAV1 (zeige CAV1 Proteine)-CAV2 locus is associated with decreased expression of CAV1 (zeige CAV1 Proteine) and CAV2 in some tissues, marginally with intraocular pressure elevation, and consequently with increased susceptibility to high-tension glaucoma.
Results present initial characterization of key proteins Cav2 and CFL1 (zeige VPS72 Proteine) as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 (zeige ZNF502 Proteine) protein which appears to interact with RSV M in the nucleus.
The implication of the caveolin genes, CAV1 (zeige CAV1 Proteine)/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss.
CAV1 (zeige CAV1 Proteine)/CAV2 SNPs were associated significantly with primary open-angle glaucoma overall, particularly among women.
Our findings did not correspond with previous positive results, suggesting that CAV1 (zeige CAV1 Proteine)-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma.
While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle.
We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2.
Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta (zeige TGFB1 Proteine) compared to empty vector.
Data show that the balance between caveolin-1 (zeige CAV1 Proteine) and caveolin-2 is important for iNOS (zeige NOS2 Proteine) expression and ultimately for sepsis outcome.
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 (zeige CAV1 Proteine) expression levels and is not because of changing targeting of caveolin 1 (zeige CAV1 Proteine) protein to plasma membrane lipid raft/caveolar domains.
Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression.
Data show that amino acids K47-K57 of Cav-1 (zeige CAV1 Proteine) are a highly conserved sequence in Cav-1 (zeige CAV1 Proteine) and Cav-3 (zeige CAV3 Proteine) proteins, and that expression of either K47-K57 deletion Cav-1 (zeige CAV1 Proteine) mutant or wild-type Cav-2 that lacks this sequence exhibits a non-polarized distribution pattern.
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1 (zeige CAV1 Proteine).
The interaction of caveolin-2 with caveolin-1 (zeige CAV1 Proteine) could play an important role in caveolae biogenesis and shear stimulated mechano-signal transduction.
miR (zeige MYLIP Proteine)-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42 (zeige CDC42 Proteine), in intestinal Salmonella infection, is reported.
caveolin-2 is an integral component of the trafficking network in the intestinal cells of C. elegans
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).
caveolae protein, 20-kD
, caveolin 2 isoform a and b
, caveolin 2