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GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
effects of GRK3 modulation appear to be specific to chemokine (zeige CCL1 Proteine)-mediated migration behaviors without influencing tumor cell proliferation or survival
data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6 (zeige HDAC6 Proteine)-induced reorganization of the vimentin (zeige VIM Proteine) intermediate filament network
Data indicate that CXCL12 (zeige CXCL12 Proteine)-induced phosphorylation at CXCR4 (zeige CXCR4 Proteine) S346/347 was mediated by GRK2/3.
In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
we found no evidence of altered levels of acetylated histone H3 (zeige HIST3H3 Proteine) at the affected allele compared to the common allele
dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder
the CRH (zeige CRH Proteine)-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor (zeige ADRA1A Proteine) kinase
beta-arrestin 2 (zeige ARRB2 Proteine) and GRK2 (zeige ADRBK1 Proteine) colocalize with S1p2 (zeige S1PR2 Proteine) in developing zebrafish embryos and depletion of GRK2 (zeige ADRBK1 Proteine) in the S1p2 (zeige S1PR2 Proteine) R150H miles apart zebrafish partially rescued cardia bifida.
GRK2 (zeige ADRBK1 Proteine) and GRK5 (zeige GRK5 Proteine) control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Data suggest that a G protein-coupled receptor (zeige GPBAR1 Proteine) kinase, perhaps GRK2 (zeige ADRBK1 Proteine) or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog (zeige SHH Proteine) signal transduction during early development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
adrenergic, beta, receptor kinase 2
, beta-adrenergic receptor kinase 2-like
, beta ARK2
, beta-adrenergic receptor kinase 2
, G-protein-coupled receptor kinase 3
, adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)
, G-protein coupled receptor kinase 2/3