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Human Polyclonal NDEL1 Primary Antibody für IF, WB - ABIN541186
Liu, Steward, Luo: Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport. in Nature cell biology 2001
Show all 3 Pubmed References
Polyclonal NDEL1 Primary Antibody für ELISA, WB - ABIN539863
Yingling, Youn, Darling, Toyo-Oka, Pramparo, Hirotsune, Wynshaw-Boris: Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. in Cell 2008
Results demonstrate that Ndel1 interacts with Tara to regulate cell movement revealing a novel role of the Ndel1-Tara complex in actin reorganization during cell movement.
results highlight S-Nitrosylation as a key activity-dependent mechanism underlying neonatal brain maturation and suggest that reduction of S-Nitrosylation of NDEL1 acts as a pathological factor mediating neurodevelopmental abnormalities caused by maternal alcohol exposure
disrupting DISC1/Ndel1 complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids
Study showed that Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia physiopathology
This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
The Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia.
Short (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and phosphodiesterase (PDE)4B proteins, but fully interact with FEZ1 and glycogen synthase kinase 3 (GSK3)beta.
Nudel markedly promotes the HSPC300-WAVE2 interaction.
analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly.
Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.
Studies indicate that binding of dynactin, LIS1 and NudEL regulate cytoplasmic dynein motor activity.
DISC1 forms octamers via dimers as building blocks. S704C forms higher-order oligomers, without affecting its affinity with NDEL1
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
The truncated monomeric form of LIS1 had little effect on dynein motility, but an artificial dimer of truncated LIS1 suppressed dynein motility, which was restored by the N-terminal fragment of NDEL1.
NDEL1 is essential for a specific late step of neuronal migration: entry into the target lamina.
This data supports a physiological role for the endooligopeptidase activity of Ndel1 and suggests it plays a key role during neurite outgrowth.
Findings suggest that physiological functions of LIS1 and NDEL1 in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control.
NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane.
This study showed that Ndel1 Maintain Postnatal CA1 Hippocampus Integrity in mice.
Data indicate that NDEL1 is inducibly expressed in the adult nervous system, and signaling via the CREB/CRE transcriptional pathway is likely involved. Role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizures
NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon.
Results suggest that NDEL1 might interact with DISC1 to activate ERK signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus
Results show that LIS1 acts via the LIS1-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs with the cell cortex to ensure precise cell division.
Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons.
palmitoylated Ndel1 reduced cytoplasmic dynein activity as judged by Golgi distribution, VSVG and short microtubule trafficking, transport of endogenous Ndel1 and LIS1 from neurite tips to the cell body and neuronal migration
Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner.
The predicted peptide product resulting from the Scottish translocation removes the interaction domain for Nudel. Nudel is able to act as a bridge between DISC1 and Lis1 to allow formation of a trimolecular complex.
NUDEL is important for NF assembly, transport and neuronal integrity. NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L).
Ndel1 deficiency results in neuronal migration defects and early embryonic lethality
Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry
Nudel facilitates cell migration by sequestering Cdc42GAP at the leading edge to stabilize active Cdc42 in response to extracellular stimuli.
Ndel1 promotes axonal regeneration; activating this endogenous repair mechanism may enhance neuroregeneration during acute and chronic axonal degeneration.
Results report that reduction of Lis1 and Ndel1 in a mitotic cell line impairs prophase nuclear envelope invagination.
These findings demonstrate a surprising role of aPKC-Aurora A-NDEL1 pathway in microtubule remodelling during neurite extension.
Ndel1b is expressed predominantly in the somites in developing zebrafish.
Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis.
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein
the mechanism of dynein regulation by Nudel and Lis1
Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner.
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.
, mitosin-associated protein 1
, mitosin-associated protein MITAP1
, nuclear distribution protein nudE-like 1
, nudE nuclear distribution E homolog-like 1
, nudE nuclear distribution gene E homolog-like 1
, protein Nudel
, LIS1-interacting protein NUDEL
, LIS1-interacting protein NUDEL; endooligopeptidase A
, nuclear distribution gene E-like homolog 1
, nudE nuclear distribution gene E homolog like 1
, endooligopeptidase A protein
, nudE nuclear distribution gene E homolog (A. nidulans)-like 1
, nuclear disribution gene E like
, NudE-like protein 1b
, nuclear distribution protein nudE-like 1-B
, nudE nuclear distribution E homolog (A. nidulans)-like 1
, nuclear distribution protein nudE-like 1-A
, nudE neurodevelopment protein 1-like 1