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Human HSP90AB1 Protein expressed in Baculovirus - ABIN1686667
Arlander, Eapen, Vroman, McDonald, Toft, Karnitz: Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. in The Journal of biological chemistry 2003
Show all 10 Pubmed References
The production of IFN-gamma (zeige IFNG Proteine) by T cells stimulated with citrullinated HSP90beta demonstrates a bias toward TH1 (zeige TH1L Proteine) immune responses that are likely involved in the pathogenesis of rheumatoid arthritis-interstitial lung disease.
the expressions of HSP90AB1 can predict prognosis in astrocytic tumors
We found that the nutrient value of the culturing medium and the length of induction had significant effect on Hsp90 (zeige HSP90 Proteine) production in Escherichia coli. Our fast, single-day purification protocol resulted in a stable, well-folded and pure sample that was resistant to degradation in a reproducible manner.
Data show that C allele of rs2282151 was associated with increased expression level of heat shock protein 90 alpha (zeige HSP90AA1 Proteine) family class B member 1 (HSP90AB1).
Hsp90beta induced endothelial cell-dependent tumor angiogenesis by activating VEGFRs transcription.
The authors find that the interaction between sB-Raf (zeige RAF1 Proteine) and the Hsp90 chaperone (zeige HSP90 Proteine) system is based on contacts with the M domain of Hsp90 (zeige HSP90 Proteine), which contributes in forming the ternary complex with Cdc37 (zeige CDC37 Proteine) as long as the kinase is not stabilized by nucleotide.
High HSP90B expression is associated with laryngeal carcinoma.
The expression level of Hsp90AB1 in lung cancer tissues was significantly higher than that in normal lung tissue and was associated with lung cancer pathological type and overall survival in lung adenocarcinoma patients.
We revealed that Hsp90A (zeige HSP90AA1 Proteine) and Hsp90B are partly colocalized with heparan sulfate proteoglycans (HSPGs) on the cell surface and that this colocalization was sensitive to heparin.
Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.
The results demonstrate that in renal cells, NHE1 (zeige SLC9A1 Proteine) is associated with several regulatory proteins including Hsp90 (zeige HSP90 Proteine), and that Hsp90 (zeige HSP90 Proteine) affects its function possibly through altered phosphorylation of the protein via the AKT (zeige AKT1 Proteine) kinase.
Extracellular Hsp70 (zeige HSP70 Proteine) and Hsp90 (zeige HSP90 Proteine), either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia.
a surface population of Hsp90 (zeige HSP90 Proteine) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (zeige TGFB1 Proteine)-activated fibroblasts.
Hsp90 (zeige HSP90 Proteine) is highly expressed on the cell surface of melanoma cells, and synthetic agents that target Hsp90 (zeige HSP90 Proteine) are promising cancer therapeutic drugs
These findings identify the Ezh2 (zeige EZH2 Proteine)-Hsp90 (zeige HSP90 Proteine) interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease.
Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (zeige HSP90 Proteine) and the PI3K/AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway in prostate cancer.
genes respond to HSP90 (zeige HSP90 Proteine) inhibition in a manner dependent on their genomic location with regard to strain-specific endogenous retroviruses-insertion sites.
PABPN1 (zeige PABPN1 Proteine) interacts with and is stabilized by heat shock protein 90 (zeige HSP90 Proteine).
Hyperacetylation of Hsp90 (zeige HSP90 Proteine) is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 (zeige HDAC6 Proteine) inhibitors increase Hsp90 (zeige HSP90 Proteine) acetylation and modulate GR chaperone dynamics.
These findings demonstrate a critical role of Hsp90 (zeige HSP90 Proteine) in lipopolysaccharide (LPS (zeige TLR4 Proteine)) signaling, and a potential involvement of the heat shock response in LPS (zeige TLR4 Proteine)-induced preconditioning.
Data from Xenopus laevis embryo suggest hsp90alpha (zeige HSP90AA2 Proteine) and hsp90Beta genes are conserved among vertebrates, and are differentially regulated in a tissue, stress, and development stage-specific manner.
Heat tolerance was assessed in Boran and Nguni cows. Protein levels of HSP90AB1, skin thickness, rectal and skin temperature were higher in the Boran cows than Nguni cows. Breed, age and coat colour did not influence HSP90AB1 concentration.
Studied the nucleotide polymorphism within the HSP90AB1 gene (SNP g.4338T>C) in Indian breeds of dairy cattle.
Association analysis revealed that the T allele at SNP g.4338T>C of the HSP90AB1 gene improved heat tolerance in cattle. Allele T was 100% in White Lamphun animals, 84% in Mountain cattle, and 18% in Holstein Friesian heifers.
This study showed that ubiquitinated ALK5 (zeige TGFBR1 Proteine) and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (zeige ACVRL1 Proteine) and ALK5 (zeige TGFBR1 Proteine) interact with heat shock protein 90(HSP90 (zeige HSP90 Proteine)).
the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Data demonstrate that Hsp90alpha (zeige HSP90AA2 Proteine) and Hsp90beta exhibit similar interactions with co-chaperones, but significantly different behaviors with respect to substrate interactions under stress conditions.
Mapped six genes (EIF4G3 (zeige EIF4G3 Proteine), HSP90, RBBP6 (zeige RBBP6 Proteine), IL8 (zeige IL8 Proteine), TERT (zeige TERT Proteine), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
Hsp90 is involved in opposing signaling pathways of cartilage homeostasis and catabolic responses are more sensitive to Hsp90 inhibition than are anabolic responses.
This gene encodes a member of the heat shock protein 90 family\; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
, heat shock 84 kDa
, heat shock 90kD protein 1, beta
, heat shock protein HSP 90-beta
, 94 kDa glucose-regulated protein
, heat shock protein 90 kDa beta member 1
, tumor rejection antigen (gp96) 1
, tumor rejection antigen 1
, Heat Shock Protein 90, endoplasmic reticulum
, heat shock protein 90B
, heat shock protein hsp90 beta
, hsp90 beta
, HSP 84
, heat shock 90kDa protein 1, beta
, heat shock protein 1, beta
, heat shock protein 90kDa alpha (cytosolic), class B member 1
, heat shock protein, 84 kDa 1
, retinal degeneration slow protein
, tumor-specific transplantation 84 kDa antigen
, heat shock cognate protein HSP 90-beta
, heat shock protein 90 beta
, heat shock 90kDa protein beta
, heat shock protein 90-beta
, heat shock protein 90kDa alpha, class B member 1
, Heat shock protein HSP 90-beta-like protein
, heat shock protein 90
, Heat shock protein HSP 90-beta