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Our studies define a mechanism for BCL11A in regulation of hematopoietic stem cell function
Bcl11a enhancer-deleted mice, Bcl11a(Deltaenh), phenocopy the BCL11A-null state with respect to alterations of globin expression.
data identify Ctip1 as a critical control over sensory cortex development
Bcl11a haploinsufficiency in mice causes impaired cognition, abnormal social behavior, and microcephaly in accordance with the human phenotype
deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice
This study showed that the expression of Sema3c (zeige SEMA3C Proteine) is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c (zeige SEMA3C Proteine) transcription
The results of this study support a role for CTIP1 on the specification of the Subcerebral Projection Neurons in layer 5 through the repression of TBR1 and the promotion of CTIP2 expression.
Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment.
BCL11A is an essential, lineage-specific factor that regulates plasmacytoid dendritic cell development, supporting a model wherein differentiation into pDCs represents a primed "default" pathway for common dendritic cell progenitors.
Bcl11a controls Flt3 (zeige FLT3 Proteine) expression in early hematopoietic progenitors and is required for pDC (zeige PDC Proteine) development in vivo.
By perturbing BCL11A-DNMT1 (zeige DNMT1 Proteine) interaction, miR (zeige MLXIP Proteine)-137 impairs cancer stemness and suppresses tumor development in Triple negative breast cancer.
APOL1 (zeige APOL1 Proteine), alpha-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia
the coding mRNA sequence of BCL11A can be targeted by miR (zeige MLXIP Proteine)-210.
BCL11A frameshift mutation associated with dyspraxia and hypotonia affecting the fine, gross, oral, and speech motor systems
IGF2BP1 (zeige IGF2BP1 Proteine) mediates posttranscriptional loss of BCL11A in cultured human adult erythroblasts
The expression levels of Bcl11a and Mdm2, Pten in B-ALL patients with CR were decreased significantly when compared with the healthy control (P < 0.05).
Studied association of BCL11A single nucleotide polymorphisms(snps) and HBS1L-MYB Intergenic snps with Hereditary Persistence of Fetal Hemoglobin (HPFH) in a cohort of sickle cell patients.
both BCL11A and HMIP (zeige MIPEP Proteine)-2 were associated with increased endogenous levels of HbF. Interestingly, we also found that BCL11A was associated with higher induction of HbF with HU.
High BCL11A expression level was correlated with lower complete remission rate and shorter overall survival in adult acute myeloid leukemia patients.
Identification of novel mutations in the HbF repressor gene BCL11A in patients with autism and intelligence disabilities.
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
B-cell CLL/lymphoma 11A (zinc finger protein)
, B-cell lymphoma/leukemia 11A
, COUP-TF interacting protein 1
, COUP-TF-interacting protein 1
, ecotropic viral integration site 9 protein
, myeloid leukemia
, B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2
, BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
, C2H2-type zinc finger protein
, ecotropic viral integration site 9 homolog
, ecotropic viral integration site 9 protein homolog
, zinc finger protein 856
, B-cell CLL/lymphoma 11A