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anti-Mouse (Murine) APOE Antikörper:
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Human Monoclonal APOE Primary Antibody für CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
Show all 13 Pubmed References
Human Polyclonal APOE Primary Antibody für IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
Show all 4 Pubmed References
Human Monoclonal APOE Primary Antibody für FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
Show all 2 Pubmed References
Human Polyclonal APOE Primary Antibody für IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Polyclonal APOE Primary Antibody für IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014
Human Monoclonal APOE Primary Antibody für FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. in The pharmacogenomics journal 2009
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Human Polyclonal APOE Primary Antibody für IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. in Journal of lipid research 2008
Mouse (Murine) Polyclonal APOE Primary Antibody für ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Human Polyclonal APOE Primary Antibody für IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal APOE Primary Antibody für IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015
results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-beta pathology; ApoE4 exerts a 'toxic' gain of function whereas the absence of ApoE is protective
Data (including data from studies using knockout mice) suggest that CD59a (zeige CD59 Antikörper), CD59b (zeige CD59 Antikörper), and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (zeige CD59 Antikörper) (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a (zeige CD59 Antikörper) = CD59a antigen; CD59b (zeige CD59 Antikörper) = CD59b antigen; ApoE = apolipoprotein E)
Vitamin K2 can inhibit intimal calcification of aortic artery induced by high-fat diet in ApoE(-/-) mice via suppression of TLR2/4 expression.
the Chromogranin A (zeige CHGA Antikörper)-derived vasostatin-2 attenuates atherosclerosis in apoE(-/-) mice and, in addition to its anti-inflammatory property, also acts as an inhibitor in monocyte/macrophage recruitment.
Although the severity of adipose loss in female and male Seipin (zeige BSCL2 Antikörper)(-/-)apoE(-/-) mice were similar, hyperlipidemia, steatohepatitis and atherosclerosis were less severe in females than in males.
Report a disturbance in sphingolipid and glycerophospholipid metabolism during the progression of atherosclerotic dyslipidemia in ApoE knockout mice fed high fat diet.
Eight-week-old ApoE-/-mice were fed a western diet while being administered AnxA5 or control (M1234) for a total of 6 weeks. AnxA5 administration reduced plaque size in the aortic root as well as the aortic arch by 36% and 55% respectively
Study is the first showing the significance of APOE in attenuating early brain injury after subarachnoid hemorrhage through a blood-brain barrier modulation-dependent manner.
Tauroursodeoxycholic acid attenuates Ang II (zeige AGT Antikörper) induced abdominal aortic aneurysm formation in ApoE(-/-) mice by inhibiting endoplasmic reticulum stress mediated apoptosis.
The combined data indicate that the K146N/R147W substitutions convert the full-length and the truncated apoE3[K146N/R147W] mutant into a dominant negative ligand that prevents receptor-mediated remnant clearance, exacerbates the dyslipidemia, and inhibits the biogenesis of HDL (zeige HSD11B1 Antikörper).
APOE epsilon4 carriers and non-carriers differ in hippocampal organization and there are differences as a function of sex and hippocampal segment.
APOE*E4 status had no impact on gray matter density in areas affected early by neurofibrillary tangle formation such as the hippocampus and mesial temporal lobe
With Abeta (zeige APP Antikörper) status unknown and risk from demographic characteristics controlled, varepsilon4 carriage increased risk for clinical disease progression in cognitively normal older adults over 72 months by 2.66 times compared to risk of non-varepsilon4 carriage. Re-analysis with Abeta (zeige APP Antikörper) status included showed that abnormally high Abeta (zeige APP Antikörper) increased risk for clinical disease progression over 72 months by 2.11 times compared to r...
ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.
Severe traumatic head injury patients with the APOE epsilon4 allele seems to be more prone to undergo decompressive hemicraniectomy.
APOE epsilon 4 allele affects the functional connectivity within posterior Default mode network, particularly the atrophy-corrected interhemispheric functional connectivity strength before the clinical expression of neurodegenerative disease.
support the hypothesis that mtDNA-nuclear retrograde signaling may mediate expression levels of APOE
In 227 unrelated individuals from Barranquilla, Colombia, the most frequent APOE allele was the epsilon3, with 85%, followed by the epsilon4 allele (13%) and epsilon2 (1.8%). The genotypes found were: epsilon3/epsilon3: 71.8%, epsilon3/epsilon4: 24.2%, epsilon2/epsilon3: 2.2%, epsilon2/epsilon4: 1.3% and epsilon4/epsilon4: 0.4%. The epsilon2/epsilon2 genotype was not found in this study.
In vitro and in vivo models show that ApoE4 promotes AD neuroinflammation while ApoE2 has a protective effect against Alzheimer's Disease neuroinflammation, acting via the vitamin D receptor (zeige VDR Antikörper) signaling pathway.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (zeige APOA1 Antikörper) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (zeige HSD11B1 Antikörper) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (zeige APOB Antikörper), ApoE, MTP (zeige MTTP Antikörper), and LDLR (zeige LDLR Antikörper), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (zeige HSD11B1 Antikörper) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (zeige APOB Antikörper)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (zeige MTTP Antikörper)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3