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Human Polyclonal ADNP Primary Antibody für ICC, IF - ABIN4278509
Cesur, Eren, Eren, Ergin, Ek, Yıldız, Şirinyıldız, Gök Balcı, Ongel: Effect of experimentally induced hypothyroidism during gestation period on activity dependent neurotrophic factor (ADNF) in newborn rat brain tissue. in Hormone molecular biology and clinical investigation 2018
Human Polyclonal ADNP Primary Antibody für ICC, IF - ABIN258198
Cattano, Valleggi, Ma, Kastsiuchenka, Abramo, Sun, Cavazzana, Natale, Maze, Giunta: Xenon induces transcription of ADNP in neonatal rat brain. in Neuroscience letters 2008
Human Polyclonal ADNP Primary Antibody für IF (p), IHC (p) - ABIN724040
Ma, Chu, Zhang, Jiang, Jia, Dang, Gao: Intranasal Delivery of Recombinant NT4-NAP/AAV Exerts Potential Antidepressant Effect. in Neurochemical research 2016
The Adnp haploinsufficient mouse mimics the human ADNP syndrome in terms of synapse density and gene expression patterns, as well as in developmental, motor, and cognitive abilities.
excessive alcohol consumption in female mice led to long-lasting reduction in hippocampal Adnp expression. We found that Adnp haploinsufficient female mice showed higher alcohol consumption and preference, compared to Adnp intact females, whereas no genotype difference was observed in males.
results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues
Hippocampal ADNP expression was greater in males than in females. Haploinsufficiency led to increased hippocampal eIF4E and ApoE expression.
the newly identified shared microtubule target of NAP/ADNP is directly implicated in synaptic plasticity, explaining the breadth and efficiency of neuroprotective/neurotrophic capacities
ADNP expression is increased in the cerebral cortex of a transgenic mouse model of Alzheimer disease.
NAP is an ADNP derived peptide that modulates the tubulin pool in mice and rats
Results support the hypothesis that ADNP expression is related to early or mild Alzheimer's disease progression by a VIP-independent mechanism.
ADNP is identified as a new key gene essential for organogenesis in the developing embryo and may be implicated as a clinical target associated with proper neurodevelopment.
Data reveal a non-significant increase in activity-dependent neuroprotective protein (ADNP) in brains at 5 h, 24 h, and 7 d post-closed head injury, and a significant increase at 29 d post-CHI.
ADNP has a part in the estrus cycle as an affecter or an effector.
The mRNA transcripts for activity-dependent neuroprotective protein (ADNP, the NAP containing protein) were shown to increase 29 days post closed head injury in the injured hemisphere of Mac-1 expressing mice.
ADNP expression is mediated through multiple receptors and signaling pathways that are regulated by different concentrations of PACAP
results place ADNP at a crucial point of gene regulation, repressing potential endoderm genes and enhancing genes associated with organogenesis/neurogenesis
All of the ADNP-immunopositive cells co-localized with Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor immunoreactivity
These results showed that VIP regulated brain ADNP expression in a regionally specific manner and indicated that both maternal and offspring VIP genotype may influence ADNP expression in the brain.
results position ADNP in direct association with neuronal cell differentiation and maturation
in patients with intellectual disability, autism spectrum disorder and features suggestive of Noonan syndrome should have DNA analysis for the ADNP gene if the Noonan syndrome panel failed to identify a specific mutation.
The role of ADNP in autophagy, and in autism, schizophrenia and Alzheimer's disease is described.
Our findings indicate that ADNP is a tumor suppressor and promising prognostic marker, and that ketamine treatment with ADNP induction is a potential therapeutic approach that may add benefit to current treatment protocols for patients with colorectal cancer
From a clinical standpoint, a differential diagnosis of patients with blepharophimosis should include ADNP mutations in addition to blepharophimosis ptosis epicanthus inversus syndrome, especially when intellectual disability is present
The parents of 44/54 ADNP-mutated children reported an almost full erupted dentition by 1 year of age, including molars and only 10 of the children had teeth within the normal developmental time range.
SHANK3, CHD8, and ADNP had distinctly higher scores than all other genes in the dataset describing the genes associated with autism spectrum disorders.
The study identified intratumoral heterogeneity (ITH) of the ADNP mutations in colorectal cancers, suggesting that ADNP mutations occurred during tumor progression rather than as an early event. The generation of ITH may influence on clinical outcome of the cancer patients.
These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease
This review covers the myriad of important ADNP-protein interactions and glimpse at their potential meaning in autism, schizophrenia and Alzheimer's disease. [review]
ADNP expression was increased in male hippocampus samples compared to female samples.
Mutations in the ADNP gene cause syndromic autism.Ample evidence exists that ADNP is of key importance for proper functioning of the nBAF complex.
This study showed ADNP that deregulated in postmortem hippocampal samples from schizophrenia patients, but that now showed a significantly increased expression in lymphocytes from related patients.
Ten patients with autism spectrum disorders and other shared clinical characteristics, including intellectual disability and facial dysmorphisms caused by a mutation in ADNP, a transcription factor involved in the SWI/SNF remodeling complex.
Chromatin immunoprecipitation demonstrates the ability of ADNP to bind to its own promoter, consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression.
Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD.
In the prefrontal cortex of schizophrenia patients the correlation between ADNP and ADNP2 mRNA levels was apparently higher than in the hippocampus (r=0.854, p<0.001), but did not reach a significant difference (p=0.25).
ADNP is expressed in many immune system cells. ADNP mRNA is reduced in PBMCs in MS. The peptide NAP, which plays an important role in neuroprotection, has potential immunomodulatory properties.
Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex.
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
activity-dependent neuroprotector homeobox protein
, ADNP homeobox 1
, activity-dependent neuroprotective protein
, NAP peptide