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enpp1 can exert its function in tissues that are remote from its site of expression.
PC-1 (zeige PCSK1 Proteine) works in conjunction with E3 ligase CHIP to regulate androgen receptor (zeige AR Proteine) stability and activity.
Single nucleotide polymorphism in ENPP1 gene is associated with Gender differences in type 2 diabetes.
Single nucleotide polymorphism in ENPP1 gene is associated with developing of bone disorders in type 2 diabetes.
ENPP1 defines a subset of human B cells that differs significantly from mouse peritoneal B-1a and proposed human B-1 cells.
We have identified TT genotype of SNP rs858339 (ENPP1 gene) as a protective factor against TMD (zeige TTN Proteine) in a population of patients with dentofacial deformities.
Evidence of a causative link between ENPP1 and alterations in insulin (zeige INS Proteine) signaling, glucose uptake, and lipid metabolism in subcutaneous abdominal Adipose tissue of gestational diabetes, which may mediate insulin (zeige INS Proteine) resistance and hyperglycemia in Gestational diabetes.
We investigated whether ENPP1 gene which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders before and after orthodontic and orthognathic surgery treatment
Results identified four mutants (p.Tyr471Cys, p.Ser504Arg, p.Tyr659Cys, p.His777Arg) in ENPP1 gene with residual NPP activity, inorganic pyrophosphate generation and plasma membrane localization.
The ENPP1 rs1044498 SNP is associated with T2D.
Results suggest that heterozygous mutations in the SMB domains of ENPP1 are necessary, but not always sufficient in themselves to cause Cole disease.
Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice.
identified ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) as the first known mammalian enzyme lacking a NUDIX domain to generate pR from ADP-ribose on modified proteins in vitro
Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.
ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.
Expression of NPP1 and 5'-nucleotidase (zeige ACPP Proteine) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (zeige ADORA2A Proteine) and a cAMP/PKA/CREB (zeige CREB1 Proteine) pathway.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
NPP1 has a role in obesity and diabetes in a mouse model
we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj (zeige ARSJ Proteine)-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene
these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
ectonucleotide pyrophosphatase/phosphodiesterase 1
, ectonucleotide pyrophosphatase/phosphodiesterase family member 1
, ectonucleotidase enpp1
, E-NPP 1
, Ly-41 antigen
, alkaline phosphodiesterase 1
, membrane component chromosome 6 surface marker 1
, membrane component, chromosome 6, surface marker 1
, phosphodiesterase I/nucleotide pyrophosphatase 1
, plasma-cell membrane glycoprotein 1
, plasma-cell membrane glycoprotein PC-1
, 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, lymphocyte antigen 41
, phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, tiptoe walking