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anti-Human ENPP1 Antikörper:
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Human Polyclonal ENPP1 Primary Antibody für ELISA, IHC - ABIN4308296
Orriss, Utting, Brandao-Burch, Colston, Grubb, Burnstock, Arnett: Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. in Endocrinology 2007
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Human Polyclonal ENPP1 Primary Antibody für WB - ABIN1881296
Ermakov, Rosenbaum, Malkin, Livshits: Family-based study of association between ENPP1 genetic variants and craniofacial morphology. in Annals of human biology 2010
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Human Polyclonal ENPP1 Primary Antibody für ELISA, IHC - ABIN185487
Meyre, Bouatia-Naji, Tounian, Samson, Lecoeur, Vatin, Ghoussaini, Wachter, Hercberg, Charpentier, Patsch, Pattou, Charles, Tounian, Clément, Jouret, Weill, Maddux, Goldfine, Walley, Boutin, Dina et al.: Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. ... in Nature genetics 2005
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Human Polyclonal ENPP1 Primary Antibody für IHC (p), ELISA - ABIN547531
Bertrand, Nitschke, Fuerst, Hermann, Schäfers, Sherwood, Nalesso, Ruether, Rutsch, DellAccio, Pap: Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice. in Annals of the rheumatic diseases 2012
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Pig (Porcine) Monoclonal ENPP1 Primary Antibody für IHC (fro), FACS - ABIN2479170
McCullough, Schaffner, Natale, Kim, Summerfield: Phenotype of porcine monocytic cells: modulation of surface molecule expression upon monocyte differentiation into macrophages. in Veterinary immunology and immunopathology 1998
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Pig (Porcine) Monoclonal ENPP1 Primary Antibody für FACS - ABIN2479171
Domínguez, Ezquerra, Alonso, McCullough, Summerfield, Bianchi, Zwart, Kim, Blecha, Eicher, Murtaugh, Pampusch, Burger: Porcine myelomonocytic markers: summary of the Second International Swine CD Workshop. in Veterinary immunology and immunopathology 1998
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enpp1 can exert its function in tissues that are remote from its site of expression.
These studies demonstrate the cooperative metabolism between diadenosine triphosphate and ENPP1 function to provide a significant source of adenosine, subserving its role in inflammatory resolution.
Pilot study examined 3 candidate genes, ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1), ATP Binding Cassette Subfamily C Member 6 (ABCC6), and 5'-Nucleotidase Ecto (NT5E) involved in pyrophosphate (PPi) and inorganic phosphate (Pi) metabolism, which may predispose to coronary arterial or valvular calcification; report 4 new genetic variants potentially related to coronary calcification.
The promiscuous ectonucleotidase NPP1: molecular insights into substrate binding and hydrolysis.
This study for the first time analyzed the effect of decreased PPi on dental development in individuals with generalized arterial calcification of infancy (GACI) due to loss-of-function mutations in the ENPP1 gene.These findings reveal a novel dental phenotype in GACI and identify ENPP1 genetic mutations associated with hypercementosis.
Study concludes that germline ENPP1 cysteine-specific mutations, primarily affecting the melanocyte lineage, cause a clinical spectrum of dyschromatosis, in which the p.Cys120Arg allele represents a recessive and more severe form of Cole disease.
Findings provide insights into how ENPP1 hydrolyzes both ATP and cGAMP to participate in the two distinct biological processes.
ENPP1 gene variants may have a potential impact on the occurrence of T2 diabetes mellitus in Northern Iranians.
ENPP1 K121Q polymorphism is associated with type 2 diabetes mellitus in Ukrainian population. In carriers of the minor Q-allele the risk of T2DM is 1.4x higher than in homozygotes in the main K-allele. The risk increases in patients with BMI >/= 25 kg/m2
this study shows that ENPP1 is biomarker candidate for endometriosis
ENPP1 rs997509 polymorphism is associated with type 2 diabetes mellitus development in Ukrainian population.
This meta-analysis revealed that the K121Q (rs1044498 C > A) in the ENPP1 gene is a risk factor for Coronary Heart Disease.
This study identifies the genetic variant rs9373000 as a potentially causal variant for mandibular condyle geometry variation for patients presenting with dento-facial deformities.
these results show that ENPP1 polymorphism influences lower anterior face height, the distance from the upper lip to the nasal floor, and lip shape
PC-1 works in conjunction with E3 ligase CHIP to regulate androgen receptor stability and activity.
Single nucleotide polymorphism in ENPP1 gene is associated with Gender differences in type 2 diabetes.
Single nucleotide polymorphism in ENPP1 gene is associated with developing of bone disorders in type 2 diabetes.
ENPP1 defines a subset of human B cells that differs significantly from mouse peritoneal B-1a and proposed human B-1 cells.
We have identified TT genotype of SNP rs858339 (ENPP1 gene) as a protective factor against TMD in a population of patients with dentofacial deformities.
Evidence of a causative link between ENPP1 and alterations in insulin signaling, glucose uptake, and lipid metabolism in subcutaneous abdominal Adipose tissue of gestational diabetes, which may mediate insulin resistance and hyperglycemia in Gestational diabetes.
We investigated whether ENPP1 gene which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders before and after orthodontic and orthognathic surgery treatment
ENPP1 deficiency confers an energetic disadvantage to PCs for long-term survival and antibody production.
Enpp1 plays a crucial role in regulating aging via Klotho expression under phosphate overload conditions.
found that, like NTPDase1 (ectonucleoside triphosphate diphosphohydrolase 1, CD39), NPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1, PC-1) is also highly expressed in primary cultured murine microglia
Enpp1 inhibits hedgehog signaling and chondrocyte hypertrophy by activating Galphas-PKA signaling.
Runt-related transcription factor 2 (Runx2) was confirmed to have synergistic effects with Osx in activating ENPP1 promoter.
Report the temporal ectopic mineralization phenotype of connective tissues in Enpp1asj-2J mouse model for generalized arterial calcification of infancy.
Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice.
Enpp1asj mutant mouse provides a new animal model for studying tympanosclerotic otitis and otitis media with effusion
identified ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) as the first known mammalian enzyme lacking a NUDIX domain to generate pR from ADP-ribose on modified proteins in vitro
Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.
ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.
Expression of NPP1 and 5'-nucleotidase by valve interstitial cells promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
NPP1 has a role in obesity and diabetes in a mouse model
we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene
these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.
ENPP1 2'3'-cGAMP-hydrolyzing activity is repsonsible for tumor progression in humans and mice.
Both mono-allelic and bi-allelic ENPP1 deficiency promote dysregulated VSMC function, with robust C/EBP homologous protein expression and enhanced neointimal hyperplasia after injury in vivo, but marked post-injury calcification limited to Enpp1-/- mice.
Its mutaion causes osteochondral diseases and malnutrition.
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
ectonucleotide pyrophosphatase/phosphodiesterase 1
, ectonucleotide pyrophosphatase/phosphodiesterase family member 1
, ectonucleotidase enpp1
, E-NPP 1
, Ly-41 antigen
, alkaline phosphodiesterase 1
, membrane component chromosome 6 surface marker 1
, membrane component, chromosome 6, surface marker 1
, phosphodiesterase I/nucleotide pyrophosphatase 1
, plasma-cell membrane glycoprotein 1
, plasma-cell membrane glycoprotein PC-1
, 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, lymphocyte antigen 41
, phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, tiptoe walking