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anti-Human RACGAP1 Antikörper:
anti-Mouse (Murine) RACGAP1 Antikörper:
anti-Rat (Rattus) RACGAP1 Antikörper:
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Human Monoclonal RACGAP1 Primary Antibody für ELISA, WB - ABIN565414
Wolfe, Takaki, Petronczki, Glotzer: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. in PLoS biology 2009
Show all 4 Pubmed References
Human Polyclonal RACGAP1 Primary Antibody für IHC (p), IHC - ABIN257840
Reibel, Dorseuil, Stancou, Bertoglio, Gacon: A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation. in Biochemical and biophysical research communications 1991
Human Polyclonal RACGAP1 Primary Antibody für ICC, IF - ABIN443325
Yang, Cao, He, Li, Feng, Zhang, Zhang, Wang, Yang, Zhu, Nie, Jiang, Tian, Zhang, Liu, Ji, Zhu, Xia, Zhang: Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. in Gastroenterology 2018
RACGAP1 promotes proliferation of hepatocellular carcinoma cells by reducing activation of the Hippo and YAP pathways and promoting cytokinesis in coordination with nuclear basket protein, TPR.
The rs615382 variant disrupts the recombination signal binding protein with immunoglobulin kappa J binding site in Rac GTPase activating protein 1. Disruption of notch 1 (zeige NOTCH1 Antikörper) mediated-repression of RACGAP1 may contribute to Prostate Cancer in African Americans.
Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA (zeige RHOA Antikörper) and Erk (zeige EPHB2 Antikörper) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (zeige MKI67 Antikörper) and TOP2A (zeige TOP2A Antikörper), RacGAP1 allowed for a clearer prognostic statement.
RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3/survivin signaling pathway.
High RACGAP1 expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP (zeige TBC1D21 Antikörper) is involved in mammalian spermiogenesis by modulating RAB10 (zeige RAB10 Antikörper).
This study showed that the overexpressions of Ki67 (zeige MKI67 Antikörper), RacGAP1, and TOP2a (zeige TOP2A Antikörper) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (zeige AURKA Antikörper) and Wnt (zeige WNT2 Antikörper)-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 Is a Novel Downstream Effector of E2F7 (zeige E2F7 Antikörper)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC (zeige APC Antikörper)(CDH1 (zeige CDH1 Antikörper)) targets MgcRacGAP for destruction in the late M phase.
TLR4 (zeige TLR4 Antikörper) signaling shapes B cell dynamics via MyD88 (zeige MYD88 Antikörper)-dependent pathways and Rac (zeige AKT1 Antikörper) GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (zeige AKT1 Antikörper), CDC42 (zeige CDC42 Antikörper), and RhoG small GTPase activities
Rac (zeige AKT1 Antikörper) regulates vascular endothelial growth factor (zeige VEGF Antikörper) stimulated motility
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (zeige PIK3CA Antikörper)-Cdc42 (zeige CDC42 Antikörper)/Rac (zeige AKT1 Antikörper) pathways may play a role in determining the size and shape of tooth germ
Gab2 (zeige GAB2 Antikörper) via Shp-2 (zeige PTPN11 Antikörper) is critical for transmitting signals from Kit Tyr (zeige TYR Antikörper)(567) to activate the Rac (zeige AKT1 Antikörper)/JNK (zeige MAPK8 Antikörper) pathway controlling mast cell proliferation
Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.
Rac (zeige AKT1 Antikörper) became activated within 2 min after peripheral membrane extensions adhered to new ECM (zeige MMRN1 Antikörper) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
In vivo cell recordings reveal that gradual loss of wild-type RacGAP1 leads progressively from a failure of abscission, then to cleavage furrow ingression, and finally complete absence of furrow formation. Despite the lack of cytokinesis, gross patterning occurs overtly normally in ogre mutants and cells continue to cycle slowly, some even attaining four or eight nuclei.
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, Rac GTPase-activating protein 1
, Rac GTPase activating protein 1
, rac GTPase-activating protein 1-like