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anti-Human RAC1 Antikörper:
anti-Mouse (Murine) RAC1 Antikörper:
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Taken together, our results indicate that integrin beta6 promotes tumor invasiveness in a Rac1-dependent manner and is a potential biomarker for tumor metastasis.
Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1(P29S), and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1(P29S) mutation.
Downregulation of PLEKHA7 (zeige PLEKHA7 Antikörper) in PACG may affect BAB (zeige RERE Antikörper) integrity and aqueous humor outflow via its Rac1/Cdc42 (zeige CDC42 Antikörper) GAP activity, thereby contributing to disease etiology.
Our data indicated that miR (zeige MLXIP Antikörper)-451 relays environmental signals by upregulating the activity of AMPK (zeige PRKAA1 Antikörper) signaling, thereby modulating the activation of mTOR (zeige FRAP1 Antikörper) and Rac1/cofilin (zeige CFL1 Antikörper) which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
MBQ-167 is 10x more potent than other currently available Rac (zeige AKT1 Antikörper)/Cdc42 (zeige CDC42 Antikörper) inhibitors and has the potential to be developed as an anticancer drug, as well as a dual inhibitory probe for the study of Rac (zeige AKT1 Antikörper) and Cdc42 (zeige CDC42 Antikörper)
Filamin C (zeige FLNC Antikörper) promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rac1/cdc42 (zeige CDC42 Antikörper) activites in esophageal squamous cell carcinoma.
We observed Bonferroni-corrected statistically significant interactions between albuminuria, urine cadmium levels and polymorphisms in gene SLC30A7 and RAC1.
TIPE2 (zeige TNFAIP8L2 Antikörper) suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF (zeige VEGFA Antikörper) expression.
High RAC1 expression is associated with increased cell migration in breast neoplasms.
role of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor
Rac1 may have vital roles in the proliferation, migration, adhesion, and odontoblastic differentiation of MDPC-23 (dental papilla) cells
Rac1 exerts a dual role in skin carcinogenesis: its activation is required for HPV-8- and UV-light induced apilloma formation but, suppresses the development of squamous cell carcinomas
Taken together, the results show that mL2a-pCA induced macrophage activation via Rac1 phosphorylation-dependent pathways.
reduction of VAV2 (zeige VAV2 Antikörper) in absence of CUX1 (zeige CUX1 Antikörper) was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 (zeige CUX1 Antikörper) regulates normal intestinal epithelial cell restitution
Functionally mutating the TRAF6 ubiquitination site on Rac1 or inactivating Rac1 with a specific inhibitor reversed the deleterious effects of TRAF6 overexpression during cerebral ischemia-reperfusion injury. TRAF6 upregulation binds and ubiquitinates Rac1 directly, which promotes neuron death through neuroinflammation and neuro-oxidative signals.
This inhibitory action of Vav2 (zeige VAV2 Antikörper) shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS (zeige ROS1 Antikörper) production. These results suggest that elevated Hcys levels activate Vav2 (zeige VAV2 Antikörper) and thereby increase NOX activity leading to ROS (zeige ROS1 Antikörper) production, which triggers NLRP3 (zeige NLRP3 Antikörper) inflammasome activation, podocyte dysfunction and glomerular injury.
activation of Rac1 promotes leukemia development through enhancing leukemia cells' homing and retention in niche.
Spreading of PDGFR-alpha (zeige PDGFRA Antikörper)-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1-guanine exchange factor (GEF (zeige ARHGEF2 Antikörper))-inhibition. PDGFR-alpha (zeige PDGFRA Antikörper)-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Collectively, these findings provide a mechanistic account of how Rac1-dependent membrane raft localization regulates differential activation of distinct phosphoinositide 3-kinase isoforms and offer insight into why PTEN-deficient cancers depend on p110beta.
GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes
Rac1 modification by electrophiles such as 15-deoxy-delta(12,14)-prostaglandin J2 may alter redox signaling and vascular endothelial cells function.
Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Rac1 was activated by secretory stimuli and modulated the secretory pathway downstream of Ca2 (zeige CA2 Antikörper)+ influx, partly through regulation of cytoskeletal organization
G protein betagamma subunits, Src kinase (zeige CSK Antikörper) and the GEF (zeige SLC2A4RG Antikörper) Tiam1 (zeige TIAM1 Antikörper) are upstream modulators of S1P (zeige MBTPS1 Antikörper)-mediated Rac1 activation, and Rac1 has a role in S1P (zeige MBTPS1 Antikörper)-mediated activation of PI 3 (zeige PI3 Antikörper)-kinase/Akt (zeige AKT1 Antikörper)/endothelial nitric-oxide synthase (zeige NOS3 Antikörper) signaling in vascular endothelial cells
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK (zeige ILK Antikörper))-depleted cells, suggesting that an additional ILK (zeige ILK Antikörper)-dependent signal is required for cell spreading.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
small G protein (zeige RAC2 Antikörper) Rac1 is a key regulator of beta(3)Adrenergic receptor (zeige ADRB3 Antikörper) signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS (zeige NOS3 Antikörper) pathways in the vascular wall
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 (zeige CDKN1B Antikörper) in vascular endothelial cells.
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
cell migration-inducing gene 5 protein
, ras-like protein TC25
, ras-related C3 botulinum toxin substrate 1
, ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
, rho family, small GTP binding protein Rac1
, rac2 GTP-binding protein