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anti-Human PREX1 Antikörper:
anti-Mouse (Murine) PREX1 Antikörper:
anti-Rat (Rattus) PREX1 Antikörper:
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Human Polyclonal PREX1 Primary Antibody für ICC, IF - ABIN4342143
Lindsay, Lawn, Campbell, Faller, Rambow, Mort, Timpson, Li, Cammareri, Ridgway, Morton, Doyle, Hegarty, Rafferty, Murphy, McDermott, Sheahan, Pedone, Finn, Groben, Thomas, Hao, Carson, Norman et al.: P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. ... in Nature communications 2011
Show all 3 Pubmed References
Human Polyclonal PREX1 Primary Antibody für ELISA, IHC (p) - ABIN4342144
Qin, Xie, Wang, Hoshino, Wolff, Zhao, Scofield, Dowd, Lin, Tu: Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. in Oncogene 2009
Authors suggest that control of P-Rex1 activity depends on a highly dynamic interplay among distinct signalling routes and its multisite phosphorylation is controlled by the action of different kinases.
PREX1 integrates dopamine receptor and phosphoinositide 3-kinase signaling to promote glioblastoma tumor cell invasion.
There is a significant association in the expression of P-Rex1 and MMP10 (zeige MMP10 Antikörper) in human luminal breast cancer, and their co-expression is indicative of poor prognosis.
Data suggest that PREX1 and PREX2 (zeige DEPDC2 Antikörper) share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 (zeige DEPDC2 Antikörper) is altered in many cancers. [REVIEW]
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (zeige CXCR4 Antikörper) via phosphorylation of S339-CXCR4 (zeige CXCR4 Antikörper) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (zeige IL2 Antikörper)), IL-4 (zeige IL4 Antikörper), and IL-10 (zeige IL10 Antikörper) messenger RNA (mRNA) transcripts.
data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways
PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen.
An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib.
P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.
findings suggest a vital role of P-Rex1 signaling in CA1 (zeige CA1 Antikörper) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs
These findings identify P-Rex1 as a novel player of pulmonary fibrosis.
A novel mechanism of P-Rex1 regulation through the GPCR (zeige GPBAR1 Antikörper)-adaptor protein Norbin (zeige NCDN Antikörper).
Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
regulates GPCR-driven Rac signalling and actin polarity in neutrophils
Platelet P-Rex and Vav (zeige VAV1 Antikörper) family Rac (zeige AKT1 Antikörper)-GEFs play important proinflammatory roles in leukocyte recruitment.
We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.
P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers.
In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice.
P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway.
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
, ptdIns(3,4,5)-dependent Rac exchanger 1
, SET domain containing 6