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Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927
Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001
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the CCR7 (zeige CCR7 Proteine)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (zeige FN1 Proteine) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (zeige PLCG1 Proteine)
Data suggest that lymphotoxin (zeige LTB Proteine)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.
CCL21 and, to a lesser extent, CCL19 (zeige CCL19 Proteine) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.
CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development
CXCL9 (zeige CXCL9 Proteine) has a role in graft rejection in the absence of CCL19 (zeige CCL19 Proteine) and CCL21
T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (zeige LTB Proteine)(-/-) mice can be attributed to the impaired expression of CCL21.
alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (zeige CCL21A Proteine) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.
following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (zeige CCR7 Proteine) ligands CCL19 (zeige CCL19 Proteine)/CCL21
Results suggest that CCR7 (zeige CCR7 Proteine)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.
The presence of CCL21 during the in vitro stimulation of CD4 (zeige CD4 Proteine)+ T cells with anti-CD3 (zeige CD3E Proteine) plus anti-CD28 (zeige CD28 Proteine) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (zeige FASL Proteine).
The research findings demonstrate for the first time that the chemokines CCL19 (zeige CCL19 Proteine), CCL21 and CCR7 (zeige CCR7 Proteine) play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
Low CCL21 expression was a potential independent adverse prognostic biomarker for overall survival and progression-free survival for metastatic renal cell carcinoma (zeige MOK Proteine) patients treated with targeted therapy.
The migratory index to the CCR7 (zeige CCR7 Proteine) ligands, CCL19 (zeige CCL19 Proteine) and CCL21, was higher in T-cells from donors whose recipients will develop GvHD.
these results demonstrated that CCL21/CCR7 may activate EMT in lung cancer cells via the ERK1/2 signaling pathway.
CCL21/CCR7 (zeige CCR7 Proteine) interaction was shown to allow NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia.
These data show that CCR7 (zeige CCR7 Proteine)-CCL19 (zeige CCL19 Proteine)/CCL21 axis facilitates retention CD4 (zeige CD4 Proteine)(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
CCL21 correlated significantly with Bladder Pain Syndrome: gene expression in bladder biopsies of patients with Bladder Pain Syndrome was increased in the patients and correlated with clinical profiles.
CCL21/IL21 (zeige IL17C Proteine)-armed oncolytic adenovirus enhances antitumor activity against TERT (zeige TERT Proteine)-positive tumor cells.
plasmin (zeige PLG Proteine) cleaves surface-bound CCL21 to release the C-terminal peptide responsible for CCL21 binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form.
the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 (zeige CCL19 Proteine) and CCL21 was decreased.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
C-C motif chemokine 21b
, C-C motif chemokine 21c
, Small-inducible cytokine A21b
, beta chemokine exodus-2
, beta-chemokine exodus-2
, small inducible cytokine A21c
, small-inducible cytokine A21c
, thymus-derived chemotactic agent 4
, C-C motif chemokine 21
, Efficient Chemoattractant for Lymphocytes
, secondary lymphoid tissue chemokine
, small inducible cytokine subfamily A (Cys-Cys), member 21
, CC chemokine ligand 21
, putative CCL21 chemokine
, chemokine CCL21/6CKINE
, small-inducible cytokine A21
, small inducible cytokine A21
, chemokine (C-C motif) ligand 21
, chemokine (C-C motif) ligand 21b (serine)