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NOG Protein

NOG Spezies: Human Wirt: Escherichia coli (E. coli) > 95 % by SDS-PAGE and HPLC analyses. Active
Produktnummer ABIN988177
  • Target Alle NOG Proteine anzeigen
    NOG (Noggin (NOG))
    Biologische Aktivität
    Active
    Spezies
    • 14
    • 13
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Quelle
    • 18
    • 9
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequenz
    MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCS
    Produktmerkmale
    Fully biologically active when compared to standard. The ED50 determined by inhibiting BMP-4-induced alkaline phosphatase production ofmurine ATDC5 cells is less than 80 ng/ml, corresponding to a specific activity of >1.3×104 IU/mg in the presence of 5ng/ml BMP-4.
    Reinheit
    > 95 % by SDS-PAGE and HPLC analyses.
    Endotoxin-Niveau
    Level Less than 1EU/µg of rHu NOGGIN as determined by LAL method
    Top Product
    Discover our top product NOG Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
    Lagerung
    4 °C
  • Target
    NOG (Noggin (NOG))
    Andere Bezeichnung
    NOGGIN (NOG Produkte)
    Synonyme
    SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
    Hintergrund
    Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Synonym: NOGGIN, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.
    Molekulargewicht
    Approximately 46.2 kDa non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
    Pathways
    Stem Cell Maintenance, Tube Formation
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