CXCL11 Protein

Produktnummer ABIN987973

Produktdetails

Target: CXCL11 (Chemokine (C-X-C Motif) Ligand 11 (CXCL11))

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KN

Produktmerkmale: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is less than 10 ng/ml, corresponding to a specific activity of >, 1.0 × 105 IU/mg.

Reinheit: > 97 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuI-TAC/CXCL11 as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: CXCL11 (Chemokine (C-X-C Motif) Ligand 11 (CXCL11))

Andere Bezeichnung: I-TAC/CXCL11 (CXCL11 Produkte)

Synonyme: H174 Protein, I-TAC Protein, IP-9 Protein, IP9 Protein, SCYB11 Protein, SCYB9B Protein, b-R1 Protein, Cxc11 Protein, I-tac Protein, Ip9 Protein, Itac Protein, Scyb11 Protein, Scyb9b Protein, betaR1 Protein, C-X-C motif chemokine ligand 11 Protein, chemokine (C-X-C motif) ligand 11 Protein, CXCL11 Protein, Cxcl11 Protein

Hintergrund: CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleaved to form the mature 73 aa residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with IP-10 and MIG (two other known human non-ELR CXC chemokines), respectively. CXCL11 is expressed at low levels in normal tissues including thymus, spleen and pancreas. The expression of CXCL11 mRNA is radically up regulated in IFN-γ and IL-1 stimulated astrocytes. Moderate increase in expression is also observed in stimulated monocytes. CXCL11 has potent chemoattractant activity for IL-2 activated T cells and transfected cell lines expressing CXCR3, but not freshly isolated T-cells, neutrophils or monocytes. Synonym: I-TAC/CXCL11, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.

Molekulargewicht: 8.3 kDa, a single non-glycosylated polypeptide chain containing 73 amino acids.