Poly A Specific Ribonuclease (PARN) protein (His tag)

Details zu Produkt Nr. ABIN805470, Anbieter: Anmelden zum Anzeigen
Proteinname
  • parn-A
  • xparn
  • DAN
  • RGD1565449
  • zgc:56067
  • 1200003I18Rik
  • poly(A)-specific ribonuclease L homeolog
  • poly(A)-specific ribonuclease
  • poly(A)-specific ribonuclease (deadenylation nuclease)
  • parn.L
  • PARN
  • Parn
  • parn
Spezies
Human
7
1
Quelle
Insect cells (Sf9)
2
2
2
1
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses PARN Protein ist gelabelt mit His tag.
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Produktmerkmale DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag
Reinigung Purified by proprietary chromatographic techniques
Reinheit > 95 %
Sterilität Sterile filtered
Hintergrund DNA toposisomerase I is a key nuclear enzyme that interconverts supercoiled DNA to the required topological conformations for normal DNA replication and transcription. This enzyme is the target antigen for the so-called Scl-70 autoantibodies. Scl-70 antibodies are a specific marker in Scleroderma patients (specificity 98-100 %) and are associated with the presence of diffuse skin involvement and pulmonary fibrosis.In human tissues the DNA topoisomerase I is initially synthesized as a protein with 100 kDa molecular weight. Most of this precursor is then proteolytically processed to a species with 70 kDa molecular weight from which the Scl-70 antigen has derived its name

Synonyms: DNA topoisomerase 1, EC 5.99.1.2, DNA topoisomerase I, TOP1, Scl-70
Molekulargewicht 23 kDa
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer TOP1 is supplied in 16 mM HEPES buffer pH 7.5, 406 mM sodium chloride, and 20 % glycerol.
Handhabung Please avoid freeze thaw cycles.
Lagerung 4 °C
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