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PRNP Protein (AA 23-230) (Fc Tag)

PRNP Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Produktnummer ABIN7275480
  • Target Alle PRNP Proteine anzeigen
    PRNP (Prion Protein (PRNP))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 23-230
    Spezies
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 38
    • 6
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses PRNP Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Human PRNP Protein
    Sequenz
    Lys23-Ser230
    Produktmerkmale
    Recombinant Human PRNP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Lys23-Ser230.
    Reinheit
    > 95 % as determined by Tris-Bis PAGE
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Human PRNP, hFc Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-PRNP Antibody, hFc Tag with the EC50 of 25.8ng/ml determined by ELISA. See testing image for detail.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PRNP (Prion Protein (PRNP))
    Andere Bezeichnung
    PRNP (PRNP Produkte)
    Synonyme
    ASCR Protein, AltPrP Protein, CD230 Protein, CJD Protein, GSS Protein, KURU Protein, PRIP Protein, PrP Protein, PrP27-30 Protein, PrP33-35C Protein, PrPc Protein, p27-30 Protein, Prn Protein, Prn-p Protein, prp Protein, cjd Protein, prion Protein, prp(c) Protein, MGC84114 Protein, PRP Protein, PRPC Protein, Prp Protein, SIP Protein, PRNP Protein, AA960666 Protein, AI325101 Protein, PrP Protein, PrPC Protein, PrPSc Protein, Prn-i Protein, Sinc Protein, prP27-30 Protein, prP33-35C Protein, PrP-1 Protein, PrP1 Protein, prnprs1 Protein, stPrP-1 Protein, zgc:123004 Protein, prion protein Protein, prion protein S homeolog Protein, prion protein b Protein, PRNP Protein, Prnp Protein, prnp.S Protein, prnpb Protein
    Hintergrund
    Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of bovine spongiform encephalopathy (BSE). According to the latest reports, the genetic susceptibility of cattle to BSE is associated with polymorphisms ofthe regulatory region of the PRNP gene and the level ofits expression.
    Molekulargewicht
    49.4 kDa. Due to glycosylation, the protein migrates to 60-67 kDa based on Tris-Bis PAGE result.
    UniProt
    P04156
    Pathways
    Transition Metal Ion Homeostasis, Activated T Cell Proliferation
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