Prolactin Receptor Protein (PRLR) (AA 25-235) (Fc Tag)

Produktnummer ABIN7275467

Produktdetails

Target: Prolactin Receptor (PRLR)

Protein-Typ: Recombinant

Proteineigenschaft: AA 25-235

Spezies: Hund

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Prolactin Receptor Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Canine PRLR Protein

Sequenz: Gln25-Thr235

Produktmerkmale: Recombinant Canine PRLR Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln25-Thr235.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Prolactin Receptor (PRLR)

Andere Bezeichnung: PRLR (PRLR Produkte)

Synonyme: hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein

Hintergrund: Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.

Molekulargewicht: 53.89 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.

NCBI Accession: XM_038663941

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus