PD-1 Protein (AA 21-167) (Fc Tag)
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- Target Alle PD-1 (PDCD1) Proteine anzeigen
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 21-167
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Spezies
- Cynomolgus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PD-1 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Cynomolgus PD-1/PDCD1 Protein
- Sequenz
- Pro21-Gln167
- Produktmerkmale
- Recombinant Cynomolgus PD-1/PDCD1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro21-Gln167.
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Cynomolgus PD-1, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-PD1 Antibody, hFc Tag with the EC50 of 16.8ng/ml determined by ELISA. The affinity constant of 1.28 μM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product PDCD1 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Andere Bezeichnung
- PD-1 (PDCD1 Produkte)
- Synonyme
- CD279 Protein, PD-1 Protein, PD1 Protein, SLEB2 Protein, hPD-1 Protein, hPD-l Protein, Ly101 Protein, Pdc1 Protein, programmed cell death 1 Protein, PDCD1 Protein, Pdcd1 Protein
- Hintergrund
- Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
- Molekulargewicht
- 42.4 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
- UniProt
- B0LAJ3
- Pathways
- Cancer Immune Checkpoints
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