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NCR3 Protein (His-Avi Tag)

NCR3 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Produktnummer ABIN7275353
  • Target Alle NCR3 Proteine anzeigen
    NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
    Protein-Typ
    Recombinant
    Spezies
    • 21
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 12
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses NCR3 Protein ist gelabelt mit His-Avi Tag.
    Sequenz
    Leu19-Thr138
    Reinheit
    > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Human NKp30, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-NKp30 Antibody, hFc Tag with the EC50 of 7.8ng/ml determined by ELISA. The affinity constant of 0.292 μM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 5 % trehalose is added as protectant before lyophilization.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))
    Andere Bezeichnung
    NKp30 (NCR3 Produkte)
    Synonyme
    MGC133750 Protein, 1C7 Protein, CD337 Protein, LY117 Protein, MALS Protein, NKp30 Protein, Nkp30 Protein, natural cytotoxicity triggering receptor 3 Protein, NCR3 Protein, Ncr3 Protein
    Hintergrund
    CD337, LY117, NCR3, NKp30, 1C7, MALS,NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
    Molekulargewicht
    20 kDa. Due to glycosylation, the protein migrates to 26-40 kDa based on Tris-Bis PAGE result.
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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