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MASP2 Protein (AA 287-686) (His tag)

MASP2 Spezies: Cynomolgus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Produktnummer ABIN7275291
  • Target Alle MASP2 Proteine anzeigen
    MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 287-686
    Spezies
    • 7
    • 4
    • 3
    Cynomolgus
    Quelle
    • 6
    • 5
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses MASP2 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Cynomolgus MASP2 Protein
    Sequenz
    Thr287-Phe686
    Produktmerkmale
    Recombinant Cynomolgus MASP2 Protein is expressed from E.coli with His tag at the C-Terminus.It contains Thr287-Phe686.
    Reinheit
    > 95 % as determined by Tris-Bis PAGE
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Cynomolgus MASP2, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-MASP2 Antibody, hFc Tag with the EC50 of 10.4ng/ml determined by ELISA. See testing image for detail.
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    Discover our top product MASP2 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in 20 mM Tris, 200 mM NaCl ( pH 9.0). Normally 8 % trehalose is added as protectant before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))
    Andere Bezeichnung
    MASP2 (MASP2 Produkte)
    Synonyme
    MAP19 Protein, MASP-2 Protein, MASP1P1 Protein, sMAP Protein, MAp19 Protein, mannan binding lectin serine peptidase 2 Protein, mannan-binding lectin serine peptidase 2 Protein, MASP2 Protein, Masp2 Protein
    Hintergrund
    The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is observed with the middle east respiratory syndrome (MERS), severe acquired respiratory syndrome (SARS), and SARS-CoV-2. Activation of the lectin pathway via mannose-binding lectin associated serine protease 2 (MASP2) is witnessed under discrete viral infections including COVID-19.
    Molekulargewicht
    46.8 kDa. Due to autocatalytic cleavage, the protein migrates to 21-24 kDa&28-30 kDa based on Tris-Bis PAGE result.
    UniProt
    A0A2K5UJY0
    Pathways
    Komplementsystem
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