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ITGAV/ITGB6 Protein (AA 31-993) (His tag)

ITGAV/ITGB6 Spezies: Rhesusaffen Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7275077
  • Target Alle ITGAV/ITGB6 Produkte
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 31-993
    Spezies
    • 2
    • 2
    • 1
    • 1
    Rhesusaffen
    Quelle
    • 6
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ITGAV/ITGB6 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Rhesus macaque Integrin alpha V beta 6 (ITGAV & ITGB6) Heterodimer Protein
    Sequenz
    Phe31-Pro993 (ITGAV) acidic tail & Gly22-Asn707 (ITGB6) basic tail
    Spezifität
    Uni-Prot: F6QSK2 (ITGAV), A0A1D5QZT0 (ITGB6)
    Produktmerkmale
    Recombinant Rhesus macaque Integrin alpha V beta 6 (ITGAV & ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail.
    Reinheit
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-alpha-V Antibody, hFc Tag with the EC50 of 32.4ng/ml determined by ELISA. See testing image for detail.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Andere Bezeichnung
    Integrin alpha V beta 6 (ITGAV & ITGB6) Heterodimer (ITGAV/ITGB6 Produkte)
    Hintergrund
    ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
    Molekulargewicht
    112.1 kDa (ITGAV)&79 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Tris-Bis PAGE result.
    UniProt
    F6QSK2
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