IL21 Receptor Protein (AA 41-254) (His tag)
-
- Target Alle IL21 Receptor (IL21R) Proteine anzeigen
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 41-254
-
Spezies
- Cynomolgus
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IL21 Receptor Protein ist gelabelt mit His tag.
- Verwendungszweck
- Cynomolgus IL-21R Protein
- Sequenz
- Cys41-Gly254
- Produktmerkmale
- Recombinant Cynomolgus IL-21R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys41-Gly254.
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-21 at 2μg/ml (100μl/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 20.3ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product IL21R Protein
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- Andere Bezeichnung
- IL-21R (IL21R Produkte)
- Synonyme
- IL21R Protein, il-21ra.a Protein, CD360 Protein, NILR Protein, interleukin 21 receptor Protein, interleukin 21 receptor, tandem duplicate 1 Protein, IL21R Protein, il21r.1 Protein, Il21r Protein
- Hintergrund
- IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
- Molekulargewicht
- 25.70 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
- UniProt
- G7Q0S8
- Pathways
- JAK-STAT Signalweg
-