Clusterin Protein (CLU) (AA 22-448) (His tag)

Produktnummer ABIN7274369

Produktdetails

Target: Clusterin (CLU)

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-448

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Clusterin Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse Clusterin Protein

Sequenz: Glu22-Glu448

Produktmerkmale: Recombinant Mouse Clusterin Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu22-Glu448.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin (CLU Produkte)

Synonyme: LOC100136120 Protein, clu Protein, MGC53055 Protein, zgc:73352 Protein, xclu Protein, MGC89163 Protein, CLU Protein, APO-J Protein, APOJ Protein, CLI Protein, CLU1 Protein, CLU2 Protein, KUB1 Protein, NA1/NA2 Protein, SGP-2 Protein, SGP2 Protein, SP-40 Protein, TRPM-2 Protein, TRPM2 Protein, DAG Protein, RATTRPM2B Protein, SP40 Protein, TRPM2B Protein, Trpm2 Protein, Trpmb Protein, AI893575 Protein, ApoJ Protein, Cli Protein, D14Ucla3 Protein, Sgp-2 Protein, Sgp2 Protein, Sugp-2 Protein, GP80 Protein, gpIII Protein, 40 Protein, clusterin-1 Protein, clusterin L homeolog Protein, clusterin Protein, Clusterin Protein, LOC100136120 Protein, clu.L Protein, clu Protein, CLU Protein, clus Protein, Clu Protein, LOC101113728 Protein

Hintergrund: Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.

Molekulargewicht: 50.4 kDa. Due to autocatalytic cleavage, the protein migrates to 35-40 kDa and 43-50 kDa based on Tris-Bis PAGE result.

UniProt: Q06890

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling