Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Thimet Oligopeptidase 1 Protein (THOP1) (His tag)

THOP1 Spezies: Maus Wirt: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Produktnummer ABIN7198217
  • Target Alle Thimet Oligopeptidase 1 (THOP1) Proteine anzeigen
    Thimet Oligopeptidase 1 (THOP1)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 7
    • 1
    • 1
    Maus
    Quelle
    • 3
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Aufreinigungstag / Konjugat
    Dieses Thimet Oligopeptidase 1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Mouse THOP1 Protein (His Tag)(Active)
    Sequenz
    Lys 2-Cys 687
    Produktmerkmale
    A DNA sequence encoding the mouse THOP1 (NP_073144.3) (Lys 2-Cys 687) was fused with a polyhistidine tag at the N-terminus.
    Reinheit
    > 90 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by its ability to cleave a fluorogenic peptide substrate, (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Pro-D-Lys(2,4-dinitrophenyl)-OH or Mca-PLGPK(Dnp)-OH.The specific activity is > 100 pmoles/min/μg.
    Top Product
    Discover our top product THOP1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Thimet Oligopeptidase 1 (THOP1)
    Andere Bezeichnung
    THOP1 (THOP1 Produkte)
    Synonyme
    EP24.15 Protein, MEPD_HUMAN Protein, MP78 Protein, TOP Protein, AI131655 Protein, AI327041 Protein, THOP1 Protein, thop1 Protein, MGC147297 Protein, LOC397806 Protein, mepd Protein, thimet oligopeptidase 1 Protein, thimet oligopeptidase 1 L homeolog Protein, thimet oligopeptidase Protein, peptidase Protein, Thimet oligopeptidase Protein, THOP1 Protein, Thop1 Protein, thop1 Protein, thop1.L Protein, Tc00.1047053506411.10 Protein, Tc00.1047053511237.10 Protein, Noca_4613 Protein, ANI_1_1400064 Protein, MBOO_RS10705 Protein, AOR_1_880174 Protein, AnaeK_0425 Protein, MPAL_RS03920 Protein, Hoch_5061 Protein, mepd Protein
    Hintergrund

    Background: THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.

    Synonym: AI131655,AI327041,EP24.15

    Molekulargewicht
    80.1 kDa
    NCBI Accession
    NP_073144
Sie sind hier: