SULT1A3 Protein (His tag)

Produktnummer ABIN7317564

Produktdetails

Target: SULT1A3 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 (SULT1A3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SULT1A3 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human SULT1A3 Protein (His Tag)(Active)

Sequenz: Glu2-Leu295

Produktmerkmale: A DNA sequence encoding the mature form of human SULT1A3 (NP_808220.1) (Glu2-Leu295) was expressed with a polyhistide tag at the N-terminus.

Reinheit: > 94 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 150 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SULT1A3 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 (SULT1A3))

Andere Bezeichnung: SULT1A3 (SULT1A3 Produkte)

Synonyme: ASTIV Protein, Mx-ST Protein, PST-1 Protein, St1a1 Protein, Stm Protein, Stp1 Protein, Sult1a3 Protein, SULT1A3 Protein, sulfotransferase family 1A member 1 Protein, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 Protein, Sult1a1 Protein, SULT1A4 Protein

Hintergrund:

Background: SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A4 arose from a segmental duplication. It is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). SULT1A3 is expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. SULT1A3 is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Synonym: Sulfotransferase 1A3/1A4, ST1A3/ST1A4, Aryl Sulfotransferase 1A3/1A4, Catecholamine-Sulfating Phenol Sulfotransferase, HAST3, M-PST, Monoamine-Sulfating Phenol Sulfotransferase, Placental Estrogen Sulfotransferase, Sulfotransferase Monoamine-Preferring, Thermolabile Phenol Sulfotransferase, TL-PST, SULT1A3, STM, SULT1A4,HAST,HAST3,M-PST,ST1A5,STM

Molekulargewicht: 30.5 kDa

NCBI Accession: NP_808220

Pathways: ER-Nucleus Signaling