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Mbl1 Protein (Fc Tag)

Mbl1 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
Produktnummer ABIN7321168
  • Target Alle Mbl1 Produkte
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Protein-Typ
    Recombinant
    Spezies
    • 2
    • 1
    Ratte
    Quelle
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Mbl1 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Recombinant Rat MBL1 Protein (Fc Tag)
    Sequenz
    Met1-Ala238
    Produktmerkmale
    A DNA sequence encoding the rat MBL1 (P19999) (Met1-Ala238) was expressed with the Fc region of human IgG1 at the C-terminus.
    Reinheit
    > 85 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
    Andere Bezeichnung
    MBL1 (Mbl1 Produkte)
    Synonyme
    MBL-A Protein, MBP-A Protein, pMBP-28 Protein, S-MBP Protein, Mbpa Protein, Mlb1 Protein, mannan-binding lectin (A) Protein, mannose-binding lectin (protein A) 1 Protein, MBL1 Protein, Mbl1 Protein
    Hintergrund

    Background: Mannose-binding lectin (MBL), also named mannose or mannan-binding protein (MBP), is a C-type lectin which participates in the innate immune system as an activator of the complement system and as opsonin after binding to certain carbohydrate structures on microorganisms and pathogens. Its function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms including bacteria, viruses, protozoa and fungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. Two forms of MBL, MBL-A and MBL-C, were characterized in rodents, rabbits, bovine and rhesus monkeys, whereas only one form was identified in humans, chimpanzees and chickens. The two forms are encoded by two distinct genes named MBL1 and MBL2, which have been identified in many species including the pig. The MBL1 and MBL2 genes encode mannan-binding lectins (MBL) A and C, respectively, that are collagenous lectins (collectins) produced mainly by the liver. The MBL1 gene encodes MBL-A, which has bacteria-binding properties in pigs and rodents but is mutated to a pseudogene in humans and chimpanzees. Deficiency of MBL is probably the most common human immunodeficiency and is associated with an increased risk of mucosally acquired infections including meningococcal disease. MBL could modify disease susceptibility by modulating macrophage interactions with mucosal organisms at the site of initial acquisition.

    Synonym: MBL1

    Molekulargewicht
    50.5 kDa
    UniProt
    P19999
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