ENTPD2 Protein (AA 29-460) (His tag)

Produktnummer ABIN7195468

Produktdetails

Target: ENTPD2 (Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 29-460

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses ENTPD2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NTPDase 2/ENTPD2 Protein (aa 29-460, His Tag)(Active)

Sequenz: Thr 29-Asp460

Produktmerkmale: A DNA sequence encoding the mature form of human ENTPD2 (Q9Y5L3) (Thr29-Asp460) was expressed, with a polyhistidine tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to hydrolyze the 5'phosphate groups from the substrate adenosine 5'triphosphate(ATP).The specific activity is > 5,000 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ENTPD2 (Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2))

Andere Bezeichnung: NTPDase 2/ENTPD2 (ENTPD2 Produkte)

Synonyme: MGC76207 Protein, MGC151796 Protein, CD39L1 Protein, NTPDase-2 Protein, Cd39l1 Protein, NTPDase2 Protein, ectonucleoside triphosphate diphosphohydrolase 2 Protein, Ectonucleoside triphosphate diphosphohydrolase 2 Protein, entpd2 Protein, ENTPD2 Protein, enp2 Protein, Entpd2 Protein

Hintergrund:

Background: NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.

Synonym: CD39L1;NTPDase-2;RP11-229P13.11-001

Molekulargewicht: 49.3 kDa

UniProt: Q9Y5L3