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CMA1 Protein (His tag)

CMA1 Spezies: Human Wirt: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7195123
  • Target Alle CMA1 Proteine anzeigen
    CMA1 (Chymase 1, Mast Cell (CMA1))
    Protein-Typ
    Recombinant
    Spezies
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 8
    • 6
    • 2
    Baculovirus infected Insect Cells
    Aufreinigungstag / Konjugat
    Dieses CMA1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human CMA1/Chymase 1 Protein (His Tag)
    Sequenz
    Met 1-Asn 247
    Produktmerkmale
    A DNA sequence encoding the human CMA1 (P23946) (Met 1-Asn 247) was fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 92 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product CMA1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Frozen, Liquid
    Buffer
    Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    CMA1 (Chymase 1, Mast Cell (CMA1))
    Andere Bezeichnung
    CMA1/Chymase 1 (CMA1 Produkte)
    Synonyme
    CYH Protein, MCT1 Protein, chymase Protein, MMCP-5 Protein, Mcp-5 Protein, Mcp5 Protein, Mcpt5 Protein, MCP3P Protein, CMA1 Protein, Chymase Protein, chymase 1 Protein, chymase 1, mast cell Protein, chymase-like Protein, CMA1 Protein, Cma1 Protein, LOC100008644 Protein
    Hintergrund

    Background: Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed. 

    Synonym: chymase;CYH;MCT1

    Molekulargewicht
    26.6 kDa
    UniProt
    P23946
    Pathways
    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
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