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CNDP1 Protein (His tag)

CNDP1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 93 % as determined by SDS-PAGE Active
Produktnummer ABIN7320096
  • Target Alle CNDP1 Proteine anzeigen
    CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 12
    • 1
    Maus
    Quelle
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CNDP1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Mouse CNDP1 Protein (His Tag)(Active)
    Sequenz
    Met 1-Tyr 492
    Produktmerkmale
    A DNA sequence encoding the mouse CNDP1 (Q8BUG2) (Met 1-Tyr 492) was expressed, with an N-terminal signal peptide and a C-terminal polyhistidine tag.
    Reinheit
    > 93 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by its ability to cleave carnosine (ß-Ala-L-His)in a two-step assay.The specific activity is > 250 pmoles/min/μg.
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    Discover our top product CNDP1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
    Andere Bezeichnung
    CNDP1 (CNDP1 Produkte)
    Synonyme
    cn1 Protein, cpgl2 Protein, CNDP1 Protein, CN1 Protein, CPGL2 Protein, HsT2308 Protein, AI746433 Protein, Cn1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) L homeolog Protein, carnosine dipeptidase 1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) Protein, cndp1.L Protein, CNDP1 Protein, cndp1 Protein, Cndp1 Protein
    Hintergrund

    Background: CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.

    Synonym: AI746433;Cn1

    Molekulargewicht
    56.5 kDa
    UniProt
    Q8BUG2
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