ENPP3 Protein (AA 48-875) (His tag)

Produktnummer ABIN7013636

Produktdetails

Target: ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 48-875

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ENPP3 Protein ist gelabelt mit His tag.

Produktmerkmale: Human ENPP3 / CD203c Protein, His Tag

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 8.0

Lagerung: -20 °C

Antigendetails

Target: ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))

Andere Bezeichnung: ENPP3 (ENPP3 Produkte)

Synonyme: B10 Protein, CD203c Protein, NPP3 Protein, PD-IBETA Protein, PDNP3 Protein, Npp3 Protein, RB13-6 Protein, AI876438 Protein, ENPP3 Protein, ectonucleotide pyrophosphatase/phosphodiesterase 3 Protein, ectonucleotide pyrophosphatase/phosphodiesterase 3 L homeolog Protein, ENPP3 Protein, Enpp3 Protein, enpp3 Protein, enpp3.L Protein

Hintergrund: The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).

Molekulargewicht: 96.9 kDa

NCBI Accession: NP_005012

Pathways: Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity