TNFRSF10B Protein (AA 58-212) (His tag)

Produktnummer ABIN7013518

Produktdetails

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 58-212

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TNFRSF10B Protein ist gelabelt mit His tag.

Sequenz: AA 58-212

Produktmerkmale: Biotinylated Human Transferrin R / CD71 Protein, His,Avitag™ (MALS verified)

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: MALS verified

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Andere Bezeichnung: TRAIL R2 (TNFRSF10B Produkte)

Synonyme: TNFRSF10B Protein, dr5 Protein, cd262 Protein, killer Protein, trick2 Protein, trickb Protein, xDR-M1 Protein, xDR-M2 Protein, ztnfr9 Protein, trailr2 Protein, trick2a Protein, trick2b Protein, CD262 Protein, DR5 Protein, KILLER Protein, KILLER/DR5 Protein, TRAIL-R2 Protein, TRAILR2 Protein, TRICK2 Protein, TRICK2A Protein, TRICK2B Protein, TRICKB Protein, ZTNFR9 Protein, Ly98 Protein, MK Protein, tumor necrosis factor receptor superfamily, member 10b Protein, tumor necrosis factor receptor superfamily member 10b S homeolog Protein, tumor necrosis factor receptor superfamily member 10b L homeolog Protein, tumor necrosis factor receptor superfamily member 10b Protein, TNF receptor superfamily member 10b Protein, Tnfrsf10b Protein, TNFRSF10B Protein, tnfrsf10b.S Protein, tnfrsf10b.L Protein, tnfrsf10b Protein

Hintergrund: Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.

Molekulargewicht: 19.1 kDa

Pathways: p53 Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity