Dieses SARS-CoV-2 Nucleocapsid Protein ist gelabelt mit His tag.
Verwendungszweck
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag
Spezifität
SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y)
Produktmerkmale
SARS-CoV-2 Nucleocapsid protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1). Mutations D63G, R203M, G215C, D377Y are identified in the SARS-CoV-2 Delta Variant (B.1.617.2) and sub-lineages of Delta (AY.1/AY.2/AY.3; "Delta Plus").
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.