SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N) (D63G, D377Y, R203M, R385K) (His tag)

Produktnummer ABIN7013102

Produktdetails

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: D377Y, D63G, R203M, R385K

Spezies: SARS Coronavirus-2 (SARS-CoV-2)

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SARS-CoV-2 Nucleocapsid Protein ist gelabelt mit His tag.

Verwendungszweck: SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y, R385K), His Tag

Spezifität: SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y, R385K)

Produktmerkmale: SARS-CoV-2 Nucleocapsid protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1). The mutations (D63G, R203M, D377Y, R385K) were identified in the SARS-CoV-2 variants which emerged in India (known as B.1.617.2).

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS 0.5 M Arginine, pH 7.3

Lagerung: -20 °C

Antigendetails

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Andere Bezeichnung: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N Produkte)

Synonyme: nucleocapsid phosphoprotein Protein, N Protein

Substanzklasse: Viral Protein

Hintergrund: Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Molekulargewicht: 47.2 kDa

NCBI Accession: QHO62115