Fusion Glycoprotein Protein (F) (AA 27-487) (His tag)

Produktnummer ABIN7013074

Produktdetails

Target: Fusion Glycoprotein (F)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 27-487

Spezies: Nipah Virus (NiV)

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Fusion Glycoprotein Protein ist gelabelt mit His tag.

Verwendungszweck: Nipah virus Fusion glycoprotein, His Tag

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS

Lagerung: -20 °C

Antigendetails

Target: Fusion Glycoprotein (F)

Andere Bezeichnung: Fusion glycoprotein (F Produkte)

Substanzklasse: Viral Protein

Hintergrund: Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.

Molekulargewicht: 55.9 kDa

NCBI Accession: NP_112026