ADAM17 Protein (Fc Tag)

Produktnummer ABIN6964407

Produktdetails

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ADAM17 Protein ist gelabelt mit Fc Tag.

Sequenz: ADAM17 (Lys215-Asn671)+hFc(GLU99-ALA330)

Produktmerkmale: Tagged Protein: C-Human Fc tag

Aufreinigung: affinity purification

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C for 12 months (Avoid repeated freezing and thawing)

Haltbarkeit: 12 months

Antigendetails

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Andere Bezeichnung: ADAM17 (ADAM17 Produkte)

Synonyme: ADAM18 Protein, CD156B Protein, CSVP Protein, NISBD Protein, TACE Protein, CD156b Protein, Tace Protein, adam17 Protein, si:dkey-81b15.2 Protein, adam18 Protein, cd156b Protein, csvp Protein, tace Protein, fc20b01 Protein, wu:fc20b01 Protein, zgc:63886 Protein, ADAM metallopeptidase domain 17 Protein, a disintegrin and metallopeptidase domain 17 Protein, ADAM metallopeptidase domain 17b Protein, ADAM metallopeptidase domain 17 L homeolog Protein, ADAM metallopeptidase domain 17a Protein, ADAM17 Protein, Adam17 Protein, adam17b Protein, adam17.L Protein, adam17a Protein

Hintergrund: Synonymes: ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]

Molekulargewicht: 75.79 kDa

UniProt: P78536

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus