CCR2 Protein (Fc Tag)

Produktnummer ABIN6964238

Produktdetails

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CCR2 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human CCR2 with C-terminal human Fc tag

Spezifität: CCR2 (Met1-Ala42) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Andere Bezeichnung: CCR2 (CCR2 Produkte)

Synonyme: CC-CKR-2 Protein, CCR-2 Protein, CCR2A Protein, CCR2B Protein, CD192 Protein, CKR2 Protein, CKR2A Protein, CKR2B Protein, CMKBR2 Protein, MCP-1-R Protein, ACKR5 Protein, CKRX Protein, CRAM Protein, CRAM-A Protein, CRAM-B Protein, HCR Protein, Cc-ckr-2 Protein, Ccr2a Protein, Ccr2b Protein, Ckr2 Protein, Ckr2a Protein, Ckr2b Protein, Cmkbr2 Protein, mJe-r Protein, C-C motif chemokine receptor 2 Protein, C-C motif chemokine receptor like 2 Protein, chemokine (C-C motif) receptor 2 Protein, CCR2 Protein, CCRL2 Protein, Ccr2 Protein, LOC484790 Protein

Hintergrund: Synonymes: CC-CKR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R
Description: This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq]

Molekulargewicht: predicted molecular mass of 31.0 kDa after removal of the signal peptide.The apparent molecular mass of CCR2-hFc is 35-55 kDa due to glycosylation.

UniProt: P41597

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process