KIR2DL1 Protein (Fc Tag)

Produktnummer ABIN6964163

Produktdetails

Target: KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses KIR2DL1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human KIR2DL1 Protein with C-terminal human Fc tag

Spezifität: KIR2DL1 (His22-Arg242) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))

Andere Bezeichnung: KIR2DL1 (KIR2DL1 Produkte)

Synonyme: NKAT Protein, NKAT1 Protein, p58.1 Protein, CD158A Protein, KIR221 Protein, KIR-K64 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 Protein, KIR2DL1 Protein

Hintergrund: Synonymes: CD158A, KIR-K64, KIR2DL3, KIR221, NKAT, NKAT-1, NKAT1, p58.1
Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules

Molekulargewicht: predicted molecular mass of 50.4 kDa after removal of the signal peptide. The apparent molecular mass of KIR2DL1-hFc is 55-100 kDa due to glycosylation.

UniProt: P43626