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SARS-CoV-2 Spike Protein (D614G, Super Stable Trimer) (His tag)

Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
Produktnummer ABIN6953301
  • Target Alle SARS-CoV-2 Spike Proteine anzeigen
    SARS-CoV-2 Spike
    Protein-Typ
    Recombinant
    Proteineigenschaft
    D614G, Super Stable Trimer
    Spezies
    • 223
    • 37
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    Quelle
    • 198
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses SARS-CoV-2 Spike Protein ist gelabelt mit His tag.
    Applikation
    ELISA
    Verwendungszweck
    SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)
    Produktmerkmale
    SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and D614G mutation, which has become increasingly common in SARS-CoV-2 viruses from around the world . The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
    Reinheit
    > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product SARS-CoV-2 Spike Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    This product is stable after storage at:
    -20°C to -70°C for 12 months in lyophilized state
    70°C for 3 months under sterile conditions after reconstitution.
    Haltbarkeit
    12 months
  • Target
    SARS-CoV-2 Spike
    Abstract
    SARS-CoV-2 Spike Produkte
    Synonyme
    E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
    Substanzklasse
    Viral Protein
    Hintergrund
    It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Molekulargewicht
    138.0 kDa
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