ACE2 Protein (His tag)

Produktnummer ABIN6952619

Produktdetails

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ACE2 Protein ist gelabelt mit His tag.

Verwendungszweck: Rat ACE2 / ACEH Protein, His Tag (MALS verified)

Sequenz: AA 18-740

Produktmerkmale: Rat ACE2, His Tag is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Thr 740 (Accession # Q5EGZ1-1). Predicted N-terminus: His
This protein carries a polyhistidine tag at the N-terminus.

Reinheit: > 90 % as determined by SDS-PAGE.
> 90 % as determined by SEC-MALS.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 mM Tris, 150 mM NaCl, Arginine, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt,
-70°C for 3 months under sterile conditions.

Antigendetails

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Andere Bezeichnung: ACE2 (ACE2 Produkte)

Synonyme: ACE1 Protein, CD143 Protein, DCP Protein, DCP1 Protein, ICH Protein, MVCD3 Protein, ACEH Protein, 2010305L05Rik Protein, zgc:92514 Protein, angiotensin I converting enzyme Protein, angiotensin I converting enzyme 2 Protein, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Protein, ACE Protein, ACE2 Protein, Ace2 Protein, ace2 Protein

Hintergrund: Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

Molekulargewicht: 85.5 kDa

NCBI Accession: NP_001012006

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour