GPC2 Protein (AA 22-556) (His tag)
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- Target Alle GPC2 Proteine anzeigen
- GPC2 (Glypican 2 (GPC2))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 22-556
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses GPC2 Protein ist gelabelt mit His tag.
- Sequenz
- AA 22-556
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GPC2 Protein
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Glypican 2 (GPC2) (AA 22-556) protein (His tag)
GPC2 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Glypican 2 (GPC2) (AA 24-554) protein (His tag)Crystallography grade GPC2 Spezies: Human Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Glypican 2 (GPC2) (AA 22-556) protein (His tag)Crystallography grade GPC2 Spezies: Maus Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Glypican 2 (GPC2) (AA 24-552) (Active) protein (His tag)GPC2 Spezies: Rhesusaffen Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Glypican 2 (GPC2) (AA 24-554) (Active) protein (His tag)GPC2 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Glypican 2 (GPC2) (AA 24-553) protein (Fc Tag)GPC2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
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- Target
- GPC2 (Glypican 2 (GPC2))
- Andere Bezeichnung
- Glypican 2 (GPC2 Produkte)
- Synonyme
- 2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
- Hintergrund
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Molekulargewicht
- 60.6 kDa
- NCBI Accession
- NP_766000
- Pathways
- Glycosaminoglycan Metabolic Process
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