KLRC1 Protein (AA 94-233) (His tag)

Produktnummer ABIN6938861

Produktdetails

Target: KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 94-233

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses KLRC1 Protein ist gelabelt mit His tag.

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Antigendetails

Target: KLRC1 (Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))

Andere Bezeichnung: NKG2A (KLRC1 Produkte)

Synonyme: rNKG2A Protein, NKG2-A Protein, NKG2A Protein, KLRC1 Protein, CD159A Protein, NKG2 Protein, CD159a Protein, NKG2B Protein, killer cell lectin like receptor C1 Protein, NKG2-A/NKG2-B type II integral membrane protein-like Protein, killer cell lectin-like receptor subfamily C, member 3 Protein, killer cell lectin-like receptor subfamily C, member 1 Protein, Klrc1 Protein, KLRC1 Protein, NKG2A Protein, KLRC3 Protein

Hintergrund: NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 Molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.

Molekulargewicht: 17.9 kDa

NCBI Accession: NP_002250