TIFA Protein (AA 1-184) (His tag)

Produktnummer ABIN668024

Produktdetails

Target: TIFA (TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-184

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TIFA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: TIFA, 1-184aa , Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT

Lagerung: 4 °C

Antigendetails

Target: TIFA (TRAF-Interacting Protein with Forkhead-Associated Domain (TIFA))

Andere Bezeichnung: TIFA (TIFA Produkte)

Synonyme: TIFA Protein, xtifa Protein, T2BP Protein, T6BP Protein, TIFAA Protein, T2bp Protein, Ab2-389 Protein, TRAF interacting protein with forkhead associated domain Protein, TRAF-interacting protein with forkhead-associated domain Protein, TRAF-interacting protein with forkhead-associated domain S homeolog Protein, TIFA Protein, tifa Protein, Tifa Protein, tifa.S Protein

Hintergrund: TIFA, also known as TRAF-interacting protein with FHA domain-containing protein A, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. This protein induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. Recombinant human TIFA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: TRAF-interacting protein with FHA domain-containing protein A, T2BP, T6BP, TIFAA. NCBI no.: NP_443096

Molekulargewicht: 24.0 kDa (208aa) confirmed by MALDI-TOF