SCO2 Protein (AA 42-266) (His tag)

Produktnummer ABIN667861

Produktdetails

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 42-266

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SCO2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: SCO2, 42-266aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl

Lagerung: 4 °C

Antigendetails

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Andere Bezeichnung: SCO2 (SCO2 Produkte)

Synonyme: CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein

Hintergrund: SCO2 protein belongs to the SCO1/2 family of proteins. Both SCO1 and SCO2 proteins are located on the inner membrane of the mitochondria and plays a crucial role in copper insertion or transport to the active site of cytochrome c oxidase (COX). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Recombinant human SCO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein SCO2 homolog mitochondrial, SCO1L. NCBI no.: NP_005129

Molekulargewicht: 27.4kDa (246aa), confirmed by MALDI-TOF

Pathways: Transition Metal Ion Homeostasis, Warburg Effekt