Bcl-2 Protein (AA 1-211) (His tag)

Produktnummer ABIN667734

Produktdetails

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-211

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Bcl-2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: Bcl-2, 1-211 aa, Human, His-tagged, Recombinant, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 20% glycerol 2 mM DTT

Lagerung: 4 °C

Antigendetails

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Andere Bezeichnung: Bcl-2 (BCL2 Produkte)

Synonyme: Bcl-2 Protein, PPP1R50 Protein, bcl-2 Protein, AW986256 Protein, C430015F12Rik Protein, D630044D05Rik Protein, D830018M01Rik Protein, BCL-2 Protein, Bcl2 Protein, BCL2, apoptosis regulator Protein, B cell leukemia/lymphoma 2 Protein, B-cell CLL/lymphoma 2a Protein, B-cell CLL/lymphoma 2 protein Protein, BCL2 Protein, Bcl2 Protein, bcl2a Protein, BCL-2 Protein

Hintergrund: Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Recombinant Bcl-2 protein was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: B-cell lymphoma protein 2 alpha , B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, Bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, B-cell, 2, Oncogene B-cell leukemia 2. NCBI no.: NP_000624

Molekulargewicht: 25.4 kDa (231 aa), confirmed by MALDI-TOF.

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling