PPP3R1 Protein (AA 1-170) (His tag)

Produktnummer ABIN666631

Produktdetails

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-170

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PPP3R1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: PPP3R1, 1-170aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Lagerung: 4 °C

Antigendetails

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Andere Bezeichnung: PPP3R1 (PPP3R1 Produkte)

Synonyme: si:ch211-274c22.8 Protein, canb Protein, CALNB1 Protein, CNB Protein, CNB1 Protein, CaNB1 Protein, Cnb1 Protein, MCIP1 Protein, protein phosphatase 3, regulatory subunit B, alpha a Protein, protein phosphatase 3 regulatory subunit B, alpha S homeolog Protein, protein phosphatase 3 regulatory subunit B, alpha Protein, protein phosphatase 3, regulatory subunit B, alpha Protein, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Protein, ppp3r1a Protein, ppp3r1.S Protein, PPP3R1 Protein, Ppp3r1 Protein

Hintergrund: PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits, calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. Recombinant human PPP3R1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein phosphatase 3 regulatory subunit B alpha, Calcineurin subunit B type 1, CALNB1, CNB, CNB1. NCBI no.: NP_000936

Molekulargewicht: 21.5 kDa (190aa), confirmed by MALDI-TOF

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling