Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (full length) Protein

Details zu Produkt Nr. ABIN6572885
Proteinname
  • MMP8
  • BB138268
  • CLG1
  • HNC
  • MMP-8
  • PMNL-CL
  • matrix metallopeptidase 8
  • neutrophil collagenase
  • MMP8
  • Mmp8
  • LOC100339790
Proteineigenschaft
full length
2
2
2
2
2
1
1
1
1
1
1
1
Spezies
Human
17
4
3
1
Quelle
Escherichia coli (E. coli)
12
6
2
1
1
1
Protein-Typ
Recombinant
Optionen
Produktmerkmale Recombinant Human Matrix Metalloproteinase 8. 100 units/mL after activation with APMA by solution assay method. One unit of collagenolytic activity is defined as the cleavage of 1 µg of collagen per minute by the solution method.
Reinheit > 90 % as determined by SDS-PAGE analysis.
Sterilität Sterile filtered
Proteinname
Hintergrund Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. Human recombinant Matrix Metalloproteinase-8 produced in E. coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa.
Molekulargewicht 75 kDa
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 100 units/mL
Buffer Sterile-filtered, clear solution (100 units/mL) in 0.05 M Tris-HCl buffer (pH 7.6), containing 0.2 M NaCl, 5 mM CaCl₂, 0.0025% NaN₃ and 0.1% BSA.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Please Note: Always centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
Lagerung -20 °C
Informationen zur Lagerung Store at 4°C if entire vial will be used within 1 week. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Haltbarkeit 24 months
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