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PIN1 Protein (AA 1-165) (His tag)

PIN1 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS Active
Produktnummer ABIN6388010
  • Target Alle PIN1 Proteine anzeigen
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 1-165
    Spezies
    • 11
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Quelle
    • 11
    • 6
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses PIN1 Protein ist gelabelt mit His tag.
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    MGSSHHHHHH SSGLVPRGSH MGSMADEEKL PPGWEKRMSR SSGRVYYFNH ITNASQWERP SGGSTVGGSS KNGQGEPAKV RCSHLLVKHS QSRRPSSWRQ EKITRSKEEA LELINGYIQK IKSGEEDFES LASQFSDCSS AKARGDLGPF SRGQMQKPFE DASFALRTGE MSGPVFTDSG IHIILRTE
    Reinheit
    > 95 % by SDS - PAGE
    Endotoxin-Niveau
    < 1.0 EU per 1 microgram of protein (determined by LAL method)
    Biological Activity Comment
    Specific activity is > 1,200 nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAFP-PNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.
    Top Product
    Discover our top product PIN1 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Bioactivity Validated

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Liquid. In Phosphate buffered saline (  pH 7.4) containing 10 % glycerol
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Target
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    Andere Bezeichnung
    Pin1 (PIN1 Produkte)
    Synonyme
    DOD Protein, UBL5 Protein, dod Protein, ubl5 Protein, pin1 Protein, pin1a Protein, 0610025L01Rik Protein, D9Bwg1161e Protein, pin1b Protein, zgc:73206 Protein, PPIase pin1 Protein, MdPin1 Protein, Pin1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog Protein, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog Protein, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Protein, peptidyl-prolyl cis-trans isomerase Pin1 Protein, PIN1 Protein, Pin1 Protein, pin1 Protein, pin1.S Protein, pin1.L Protein, ppiD Protein, PITG_11123 Protein, LOC103419188 Protein
    Hintergrund
    Pin1, also known as peptidyl-prolyl cis-trans isomerase NIMA-interacting1, is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Recombinant mouse PIN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
    Molekulargewicht
    20.8 kDa (188aa) Confirmed by MALDI-TOF
    NCBI Accession
    NP_075860
    UniProt
    Q9QUR7
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